Results 41 to 50 of about 2,692,204 (291)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Antioxidants, 2020 Infertility, a couple’s inability to conceive after one year of unprotected regular intercourse, is an important issue in the world. The use of natural products in the treatment of infertility has been considered as a possible alternative to conventional
Seungjin Noh +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
, 2022 Many health conditions can affect male fertility, thus highlighting the need for a thorough evaluation of patients to identify treatable or reversible lifestyle factors or medical conditions.
Salonia A., Boeri L., Pozzi E.
core +1 more source
Female Infertility and Herbal Medicine
Journal of Medicinal Plants, 2017 The causes of female infertility are multifaceted, and may extend to either of the partners or even both. Indeed, the root issues of infertility can be related to both sexes: approximately 50 percent of infertility is caused by female conditions, while ...
L Kashani, S Akhondzadeh
doaj
Advanced ScienceOvarian dysfunction is a major factor leading to female infertility. Understanding how to improve or reshape ovarian function has become an important entry point for preventing and treating female infertility caused by ovarian dysfunction.
Chunlan Mu +7 more
doaj +1 more source
Agronomy, 2021 Sandy-textured soil infertility poses a problem for sustainable crop cultivation. This problem is usually dealt with by the addition of chemical fertilizers, which are expensive and can cause serious environmental issues if not managed well.
Kevin Muyang Tawie Sulok +8 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Effects of Infertility Insurance Mandates on Fertility [PDF]
Infertility currently affects over 6 million individuals in the United States. While most health insurance plans nationwide do not cover infertility diagnoses or treatments, to date fifteen states have enacted some form of infertility insurance mandate ...
Lucie Schmidt
core +2 more sources