Results 61 to 70 of about 13,289 (294)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, Volume 20, Issue 6, Page 1535-1555, June 2026.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Examining the Effect of Chamomile on Clinical Symptoms and Hormonal Parameters Among Patients With Polycystic Ovarian Syndrome

Journal of Family and Reproductive Health, 2022
Objective: Polycystic ovarian syndrome is the most common cause of infertility and endocrine disorder among women due to anovulation. The aim of the present study is to investigate the effect of chamomile on oligomenorrhea and hirsutism symptoms as well
Malihe Afiat, Azam Akbari Lor, Mona Najaf Najafi, Masumeh Ghazanfarpour, Mina Jafarabadi   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A REVIEW ON PHARMACOLOGICAL ACTIVITIES AND MEDICINAL USES OF ANISOPUS MANNII N.E.Br.

Zanco Journal of Pure and Applied Sciences, 2022
New plants with medical potential are being researched all around the world. Anisopus mannii is a herb currently utilized in traditional Northern Nigerian medicinal formulations.
Mahmoud Dogara Abdulrahman, Harmand A. Hama, Saber W. Hamad   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Assessing fertility preservation strategies: A scoping review

Asian Pacific Journal of Reproduction
Objective: To describe the various options available for preserving female and/or male fertility, taking into account both social and medical aspects, and to identify the effects of different natural products on male infertility extracted from plants ...
Chaimaa Hilali, Chafika Nadifi, Modou Mamoune Mbaye, Nouama Bouanani, Kettani Halabi Mohamed, Noureddine Louanjli, Moncef Benkhalifa, Fatima Azzahra Lahlou   +7 more
doaj   +1 more source

Protective effects of phenolic phytochemicals on male fertility: a narrative review [PDF]

Brazilian Journal of Biology
Infertility is a global health issue and is closely related to oxidative stress, which occurs when high concentrations of free radicals surpass the protective effects of antioxidant molecules and enzymes.
J. V. Lopes-Ferreira, J. E. M. Matos, F. C. R. Dias, G. E. M. L. Siervo, M. L. M. Gomes   +4 more
doaj   +1 more source

Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century

, 2015
Infertility is estimated to affect as many as 186 million people worldwide. Although male infertility contributes to more than half of all cases of global childlessness, infertility remains a woman's social burden.
Patrizio, Pasquale, Inhorn, Marcia C
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The role of hyperglycaemia, oxidative stress, and inflammation in diabetes-related male infertility: Therapeutic properties of medicinal plants [PDF]

Journal of HerbMed Pharmacology
The prevalence of diabetes mellitus (DM) continues to rise at an alarming rate. DM leads to a decline in male reproductive function. Hyperglycaemia is an instigator of both oxidative stress and inflammation in the male reproductive system.
Murendeni Nethengwe, Kunle Okaiyeto, Chinyerum S. Opuwari, Oluwafemi O. Oguntibeju   +3 more
doaj   +1 more source