Results 61 to 70 of about 2,543,561 (297)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
BMC Plant Biology, 2021 Background Cytoplasmic male sterility (CMS), which naturally exists in higher plants, is a useful mechanism for analyzing nuclear and mitochondrial genome functions and identifying the role of mitochondrial genes in the plant growth and development ...
Benqi Wang +12 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Assessing fertility preservation strategies: A scoping review
Asian Pacific Journal of ReproductionObjective: To describe the various options available for preserving female and/or male fertility, taking into account both social and medical aspects, and to identify the effects of different natural products on male infertility extracted from plants ...
Chaimaa Hilali +7 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Protective effects of phenolic phytochemicals on male fertility: a narrative review [PDF]
Brazilian Journal of BiologyInfertility is a global health issue and is closely related to oxidative stress, which occurs when high concentrations of free radicals surpass the protective effects of antioxidant molecules and enzymes.
J. V. Lopes-Ferreira +4 more
doaj +1 more source
A Systemic Review on Use of Medicinal Plant for Management of Male Infertility
Journal of Natural RemediesA recent issue with current society is the fall in male infertility. In 50% of instances, couple infertility is caused by the failure in spermatogenesis of the male partner. The male reproductive system is impacted by a variety of factors that lead to infertility, including genitourinary tract infections, endocrine abnormalities, immunological factors,
Akansha Thakur +8 more
openaire +1 more source
Infertility Treatment in Clinical Practice
, 2021 This thesis is about male and female infertility causes and how to treat them. Nowadays, infertility is a very big issue. This thesis provides insight into this problem as well as into its solution.általános orvosangolegységes ...
Konotoptseva, Yuliya
core
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source