Results 81 to 90 of about 13,289 (294)

In vivo and in silico investigation of effects of ethanol extract of moringa oleifera leaves on female fertility, using fruit flies and molecular docking [PDF]

Journal of Clinical and Basic Research, 2023
Background: Infertility is an important issue for couples that may cause various psychological and emotional problems. Female infertility disorders play a major role in approximately 50-80% of the causes of infertility in various areas in Nigeria ...
Ben Ehigiator, Uchechukwu Loveth Iyanyi, Kelechi Samuel Mobisson, Onuchukwu Ukata   +3 more
doaj  

Prevalence and Correlates of Herbal Medicine Use among Women Seeking Care for Infertility in Freetown, Sierra Leone [PDF]

, 2018
In resource-poor countries where access to infertility care is limited, women may turn to traditional medicine to achieve motherhood. It is unknown whether Sierra Leonean women with such condition use herbal medicine.
Jia Bainga Kangbai, Kanu, Joseph Sam, James, PB, Bah, AJ, Lexina Taidy-Leigh, Sevalie, S, James, Peter Bai, Joseph Sam Kanu, Taidy-Leigh, L, Kanu, JS, Bah, Abdulai Jawo, Abdulai Jawo Bah, Peter Bai James, Stephen Sevalie, Kangbai, Jia Bainga, Taidy-Leigh, Lexina, Sevalie, Stephen, Kangbai, JB   +17 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Infertility curative plants as plant growth inhibitory agents

Pakistan Journal of Botany, 2022
Saddar Afsheen Noman, Sadaf Tabasum Qureshi, Syeda Saleha Hassney, Anila Naz Soomro   +3 more
openaire   +1 more source

Sexual reproduction in plants under high temperature and drought stress

Cell Reports
Summary: Climate-change-induced extreme heat and drought increasingly threaten plant growth and development, with a particularly significant impact on sexual reproduction.
Dong Qian, Muxuan Wang, Yue Niu, Yang Yang, Yun Xiang   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Homoeopathic Insights into the Antimicrobial Potential of Tribulus Terrestris for Urinary Tract Infection and Male Infertility

, 2023
Urinary tract infections (UTIs) pose a significant health concern, affecting millions globally and impacting male fertility. This study investigates the antimicrobial potential of Tribulus terrestris, a natural plant compound, in addressing UTIs and ...
S Sandhya, G Senthil Kumaran, Kirtida Desai
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source