Results 101 to 110 of about 30,002 (291)

Frog foams and natural protein surfactants [PDF]

, 2017
Foams and surfactants are relatively rare in biology because of their potential to harm cell membranes and other delicate tissues. However, in recent work we have identified and characterized a number of natural surfactant proteins found in the foam ...
Cooper, Alan, Kennedy, Malcolm W., Smith, Brian O., Vance, Steven J.   +3 more
core   +1 more source

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Optimisation of the enzyme-linked lectin assay for enhanced glycoprotein and glycoconjugate analysis [PDF]

, 2011
Lectin’s are proteins capable of recognising and binding to specific oligosaccharide tructures found on glycoproteins and other biomoloecules. As such they have found tility for glycoanalytical applications.
Afrough, Aileen Creavin, Ambrosi, Andrews, Brendan O’Connor, Campbell, Charlwood, Chen, Debray, Drickamer, Duk, Dwek, Eisen, Geyer, Guile, Harvey, Hsu, Huber, Iskratsch, Jiménez-Barbero, Karamanska, Karlsson, Kim, Kirkeby, Kristiansen, Laemmli, Lis, Loris, Michael O’Connell, North, Olausson, Paul Clarke, Pilobello, Pilobello, Raman, Roisin Thompson, Rosenfeld, Royle, Rudd, Rudd, Rudd, Sparbier, Studentsov, Trimble, Varki, Wu, Wu, Wu, Wu   +48 more
core   +2 more sources

One‐Step Glycoengineering of NK Cells With High‐Affinity Siglec Ligands for Cancer Immunotherapy

Advanced Science, EarlyView.
This study develops an engineered NmCSS enzyme with improved activity for bulky group modified sialic acids, enabling efficient synthesis of structurally diverse sialoside analogs in a single step. Glycan microarray screening identified Siglec high‐affinity ligands, which were incorporated onto natural killer (NK) cells via a one‐pot enzymatic system ...
Shuai Hu, Ben Huang, Lingyan Wang, Qiang Guo, Cuiping Jiang, Ruicheng Qi, Shuyao Wang, Lin‐Tai Da, Wenjie Peng   +8 more
wiley   +1 more source

Role of lectins as biologically active substances in pharmaceutical preparations

Фармакокинетика и Фармакодинамика, 2014
In an overview and critical article discusses plant lectins in terms of their importance as biologically active substances in pharmaceutical preparations.
V. A. Antonyuk
doaj  

Competitiveness and communication for effective inoculation byRhizobium, Bradyrhizobium and vesicular-arbuscular mycorrhiza fungi [PDF]

, 1994
After a short summary on the ecology and rhizosphere biology of symbiotic bacteria and vesicular-arbuscular (VA) mycorrhiza fungi and their application as microbial inocula, results on competitiveness and communication are summarized. Stress factors such
A. A. T. Vargas, A. B. Wolff, A. B. Wolff, A. D. Rovira, A. Hilali, A. J. Bjourson, A. Jacobi, A. M. Hirsch, A. Pühler, A. Savoure, C. Hubac, D. A. Kluepfel, D. A. Phillips, D. Morandi, D. Werner, D. Werner, D. Werner, E. Görge, E. Görge, E. L. Kannenberg, E. Martinez-Romero, F. D. Dakora, G. D. Bowen, H. P. Spaink, J. Denarié, J. Olivares, J. R. Rao, J. Thies, K. J. Miller, K. Kosch, K. Recourt, M. Göttfert, M. Parniske, M. Parniske, M. Parniske, N. K. Peters, P. E. Schmidt, P. E. Schmidt, P. M. Gresshoff, P. Müller, P. Schmidt, P. Somasegaran, P.J. Bottomley, R. Kape, R. Kape, R. Kape, R. Kape, S. Bernard, S. Schenk, S. U. Schenk, S. U. Schenk, W. Streit, W. Streit, W. Streit, X. Zhang, Y. M. Barnet   +55 more
core   +1 more source

Transdermal Delivery of an mRNA‐Liposome Vaccine via Dissolving Microneedle to Preserve Vaccine Activity and Enhance Immune Activation

Advanced Science, EarlyView.
An mRNA‐liposome vaccine via dissolving microneedles (ML‐DMN) enables efficient skin‐targeted delivery while preserving mRNA integrity and allowing sustained antigen expression. Unlike intramuscular (IM) injection, ML‐DMN engages skin‐resident immune cells, activates antigen‐presenting cells (APCs), and induces strong T cell and cytokine responses at ...
Jeehye Nam, JiWon Ahn, Jiwoo Shin, Nahong Lee, Youjin Lee, Sung min Cho, Paul Kim, Geonwoo Kang, Sang‐Jun Ha, Hyungil Jung   +9 more
wiley   +1 more source

Exploring the Structural Diversity and Biotechnological Potential of the Rhodophyte Phycolectome

Marine Drugs
Lectins are non-covalent glycan-binding proteins found in all living organisms, binding specifically to carbohydrates through glycan-binding domains. Lectins have various biological functions, including cell signaling, molecular recognition, and innate ...
Éllen F. Rodrigues, Flavia Alves Verza, Felipe Garcia Nishimura, Renê Oliveira Beleboni, Cedric Hermans, Kaat Janssens, Maarten Lieven De Mol, Paco Hulpiau, Mozart Marins   +8 more
doaj   +1 more source

Differential in vitro inhibitory activity against HIV-1 of alpha-(1-3)- and alpha-(1-6)-D-mannose specific plant lectins : Implication for microbicide development

Journal of Translational Medicine, 2007
Background Plant lectins such as Galanthus nivalis agglutinin (GNA) and Hippeastrum hybrid agglutinin (HHA) are natural proteins able to link mannose residues, and therefore inhibit HIV-target cell interactions.
Balzarini Jan, Krief Corinne, Schols Dominique, Lecerf Maxime, Nasreddine Nadine, Jenabian Mohammad-Ali, Saïdi Hela, Bélec Laurent   +7 more
doaj   +1 more source

Cancer targeting with biomolecules: a comparative study of photodynamic therapy efficacy using antibody or lectin conjugated phthalocyanine-PEG gold nanoparticles [PDF]

, 2015
The functionalisation of therapeutic nanoparticle constructs with cancer-specific biomolecules can enable selective tumour accumulation and targeted treatment. Water soluble gold nanoparticles (ca.
Allen, Arap, Bechet, Bertrand, Boya, Bullous, David A. Russell, Davis, Dougherty, Gary-Bobo, Girgis Obaid, Hamblin, Harris, Hogemann-Savellano, Hone, Isabelle Chambrier, Iversen, Jeyaprakash, Jin, Kim, Konska, Kopeček, Lindig, Marín, Mew, Michael J. Cook, Obaid, Oleinick, Orlova, Poiroux, Qualls, Robertson, Ross, Schafer, Schrama, Slamon, Spring, Springer, Stuchinskaya, Sudimack, Tang, Vacha, Wang, Weissenbock, Wieder, Xu, Yarden, Yu, Yu, Zhang   +49 more
core   +1 more source