Results 51 to 60 of about 507 (180)
Advanced Science, EarlyView.Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen +10 more
wiley +1 more source
Immunity gene silencing increases transient protein expression in Nicotiana benthamiana. [PDF]
Plant Biotechnol JAgroinfiltration of Nicotiana benthamiana is routinely used for transient gene expression in plant sciences and molecular pharming. Here, we depleted transcripts of 21 different immunity-related genes through virus-induced gene silencing (VIGS) to ...
Dodds IL +10 more
europepmc +3 more sources
Advanced Science, EarlyView.Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai +9 more
wiley +1 more source
Plant molecular pharming (PMP) [PDF]
, 2018 Biljke se od davnina koriste za liječenje raznih bolesti. Osim klasičnih načina sinteze lijekova pomoću bakterija, kvasaca i uzgoja u kulturi životinjskih stanica, u današnje vrijeme se razmatra i mogućnost uzgoja genetski modificiranih biljaka koje ...
Ćaleta, Anna
core
Molecular Pharming of the Recombinant Protein hEGF-hEGF Concatenated with Oleosin Using Transgenic Arabidopsis [PDF]
, 2020 We set out to assess the NIH/3T3 cell proliferation activity of Arabidopsis oil body-expressed recombinant oleosin–hEGF–hEGF protein. Normally, human epidermal growth factor (hEGF) is purified through complex process, however, oleosin fusion ...
Xinxin Lan +10 more
core +1 more source
Plant molecular pharming is a promising system for cost-effective production of veterinary vaccines
Mediterranean Agricultural Sciences, 2020 Vaccination of animals has been used for centuries and is generally considered the most cost-effective and sustainable method of disease control and prevention. About twenty-five years ago, vaccines were in a inactive form or live attenuated organisms and often were not very effective.
Tarlan MAMEDOV +2 more
openaire +3 more sources
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Advanced Science, EarlyView.Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu +15 more
wiley +1 more source
Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source
Advanced Energy Materials, EarlyView.A donor–acceptor covalent organic framework is designed as an ambipolar cathode for aluminum‐ion energy storage. The crystalline, microporous architecture enables intrinsic charge transport without conductive additives. Multi‐electron redox activity at donor and acceptor sites supports high capacity, excellent stability, and efficient reversible ...
Cataldo Valentini +11 more
wiley +1 more source