Results 31 to 40 of about 507 (180)

The B1 Domain of Streptococcal Protein G Serves as a Multi-Functional Tag for Recombinant Protein Production in Plants

Frontiers in Plant Science, 2022
Plants have long been considered a cost-effective platform for recombinant production. A recently recognized additional advantage includes the low risk of contamination of human pathogens, such as viruses and bacterial endotoxins. Indeed, a great advance
Shi-Jian Song, Hai-Ping Diao, Byeongho Moon, Areum Yun, Inhwan Hwang   +4 more
doaj   +1 more source

Data_Sheet_1_Engineering the N-glycosylation pathway of Nicotiana tabacum for molecular pharming using CRISPR/Cas9.docx [PDF]

, 2022
Molecular pharming in plants offers exciting possibilities to address global access to modern biologics. However, differences in the N-glycosylation pathway including the presence of β(1,2)-xylose and core α(1,3)-fucose can affect activity, potency and ...
Catherine Navarre (679322), Kathrin Göritzer (8750946), Melanie Grandits (434854), Audrey Y-H. Teh (13758124), Clemens Grünwald-Gruber (6007538), Sébastien Mercx (13758121), Julian K-C. Ma (8538096), Rudolf Figl (7337957)   +7 more
core   +1 more source

Plant molecular pharming in Africa for sustainable health and economic development

Vegetos
Godwin Anywar, Ntui Valentine Otang, Anywar Godwin   +2 more
exaly   +2 more sources

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Antibody degradation in tobacco plants: a predominantly apoplastic process. [PDF]

, 2011
BACKGROUND: Interest in using plants for production of recombinant proteins such as monoclonal antibodies is growing, but proteolytic degradation, leading to a loss of functionality and complications in downstream purification, is still a serious problem.
Hehle, VK, Drake Pascal M, Verena K Hehle, van Dolleweerd, CJ, Matthew J Paul, Drake, PM, Craig J van Dolleweerd, Julian KC Ma, van Dolleweerd Craig J, Ma, JK, Hehle Verena K, Ma Julian KC, Paul Matthew J, Paul, MJ, Pascal M Drake   +14 more
core   +1 more source

Functionalizing silica sol–gel with entrapped plant virus-based immunosorbent nanoparticles

Journal of Nanobiotechnology, 2022
Advancements in understanding and engineering of virus-based nanomaterials (VBNs) for biomedical applications motivate a need to explore the interfaces between VBNs and other biomedically-relevant chemistries and materials.
Matthew J. McNulty, Naomi Hamada, Jesse Delzio, Liber McKee, Somen Nandi, Marjorie L. Longo, Karen A. McDonald   +6 more
doaj   +1 more source

Molecular pharming in plants and plant cell cultures: a great future ahead?

Pharmaceutical Bioprocessing, 2014
Plant biotechnology may not be a familiar concept to the general public, but it is a rapidly developing field of research that involves the use of plants, plant tissues and plant cell cultures to make or modify products and processes. The versatility of plants and plant cells can be harnessed to produce diverse products, including valuable proteins ...
Häkkinen, Suvi T., Schillberg, Stefan, Ritala, Anneli   +3 more
openaire   +2 more sources

Assessment of the immunogenicity of residual host cell protein impurities of OsrHSA. [PDF]

PLoS ONE, 2018
Human serum albumin (HSA) is the most abundant protein in human plasma and is widely used at high doses for treating various diseases. Recombinant HSA is an alternative approach to plasma-derived HSA, providing increased safety and an unlimited supply ...
Naghmeh Abiri, Jianlei Pang, Jiquan Ou, Bo Shi, Xianghong Wang, Sucai Zhang, Yunxia Sun, Daichang Yang   +7 more
doaj   +1 more source

Synthetic gene design—The rationale for codon optimization and implications for molecular pharming in plants [PDF]

Biotechnology and Bioengineering, 2016
ABSTRACTDegeneracy in the genetic code allows multiple codon sequences to encode the same protein. Codon usage bias in genes is the term given to the preferred use of particular synonymous codons. Synonymous codon substitutions had been regarded as “silent” as the primary structure of the protein was not affected; however, it is now accepted that ...
Gina R. Webster, Audrey Y.-H. Teh, Julian K.-C. Ma   +2 more
openaire   +2 more sources

New Hope for a “Cursed” Crop? Understanding Stakeholder Attitudes to Plant Molecular Farming With Modified Tobacco in Europe

Frontiers in Plant Science, 2020
Plant molecular farming (PMF) with tobacco could provide a sustainable and cheap platform for the production of high-value proteins for medical use. It could also offer European tobacco farmers an alternative, healthful end use for their crop.
Jonathan Menary, Mario Amato, Andrés Cid Sanchez, Matthew Hobbs, Agata Pacho, Sebastian S. Fuller   +5 more
doaj   +1 more source