Combating Human Viral Diseases: Will Plant-Based Vaccines Be the Answer? [PDF]
Vaccines, 2021 Molecular pharming or the technology of application of plants and plant cell culture to manufacture high-value recombinant proteins has progressed a long way over the last three decades.
Srividhya Venkataraman +3 more
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A Brief Overview of Potential Treatments for Viral Diseases Using Natural Plant Compounds: The Case of SARS-Cov [PDF]
Molecules, 2021 The COVID-19 pandemic, as well as the more general global increase in viral diseases, has led researchers to look to the plant kingdom as a potential source for antiviral compounds.
Rambod Abiri +8 more
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An in silico overview on the usefulness of tags and linkers in plant molecular pharming [PDF]
Plant Science Today, 2014 Plant molecular pharming is a promising concept based on the large-scale production of recombinant proteins encompassing antibodies, vaccines and enzymes for human or veterinary uses and treatments. This new branch of biopharmaceutical industry offers pratcical and safety advantages over other traditional production systems.
Abdullah Makhzoum +4 more
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Molecular pharming — VLPs made in plants [PDF]
Current Opinion in Biotechnology, 2016 Plant-based expression offers a safe, inexpensive and potentially limitless way to produce therapeutics in a quick and flexible manner. Plants require only simple inorganic nutrients, water, carbon dioxide and sunlight for efficient growth. Virus-like particles (VLPs) are convincing look-alikes of viruses but without carrying infectious genomic ...
Marsian, Johanna, Lomonossoff, George P
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Analysis of the aspartic protease gene family in Nicotiana benthamiana and its application in recombinant protein expression [PDF]
Frontiers in Plant ScienceIntroductionAspartic proteases (APs) play crucial roles in plant growth, stress responses, and protein metabolism. However, endogenous APs in Nicotiana benthamiana, a key plant molecular farming platform, pose a significant challenge by degrading ...
Yu’e Li +17 more
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Realising the value of plant molecular pharming to benefit the poor in developing countries and emerging economies [PDF]
Plant Biotechnology Journal, 2013 SummaryMolecular Pharming, the production of recombinant pharmaceuticals through plant biotechnology, has the potential to transform the biologics sector of the pharmaceutical industry. More fascinating however, is how it might be used to improve access to modern medicines, and improve health of the poor in developing countries and emerging economies ...
Paul Christou +2 more
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Plant molecular pharming 2012 and beyond [PDF]
Plant Cell Reports, 2012 It is with significant pride that we bring to you this special issue on Plant Molecular Pharming. We prefer the term ‘‘Pharming’’ rather than ‘‘Farming’’ because all of the proteins and secondary products are destined to be introduced into the human health marketplace.
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Papain-like cysteine proteases in Nicotiana benthamiana: gene family members and their potential implications in recombinant protein expression [PDF]
Frontiers in Plant ScienceIntroductionPapain-like cysteine proteases (PLCPs), characterized by a conserved cysteine residue at their active sites, play crucial roles in plant growth, development, and responses to biotic and abiotic stresses.
Yalun Yang +17 more
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Oryzalin-induced polyploidy in Borago officinalis reveals cell-wall remodelling via immunofluorescence microscopy [PDF]
Frontiers in Plant ScienceIntroductionArtificial polyploidisation is a powerful biotechnological approach for improving morphological and physiological traits in medicinal plants.
Josef Baltazar Šenkyřík +3 more
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An ACE2-Fc decoy produced in glycoengineered plants neutralizes ancestral and newly emerging SARS-CoV-2 variants and demonstrates therapeutic efficacy in hamsters [PDF]
Scientific ReportsNewly emerging SARS-CoV-2 variants of concern (VOCs) continue to drive COVID-19 waves and are typically associated with immune escape and increased resistance to current therapeutics including monoclonal antibodies. By contrast, VOCs still display strong
Esther Föderl-Höbenreich +15 more
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