Results 1 to 10 of about 507 (180)

Plant Viruses in Plant Molecular Pharming: Toward the Use of Enveloped Viruses [PDF]

Frontiers in Plant Science, 2019
Plant molecular pharming has emerged as a reliable platform for recombinant protein expression providing a safe and low-cost alternative to bacterial and mammalian cells-based systems.
Ahmad Ibrahim, Valerie Odon, Richard Kormelink   +2 more
doaj   +12 more sources

Plant Molecular Pharming and Plant-Derived Compounds towards Generation of Vaccines and Therapeutics against Coronaviruses [PDF]

Vaccines, 2022
The current century has witnessed infections of pandemic proportions caused by Coronaviruses (CoV) including severe acute respiratory syndrome-related CoV (SARS-CoV), Middle East respiratory syndrome-related CoV (MERS-CoV) and the recently identified ...
Srividhya Venkataraman
doaj   +9 more sources

Engineering the N-glycosylation pathway of Nicotiana tabacum for molecular pharming using CRISPR/Cas9 [PDF]

Frontiers in Plant Science, 2022
Molecular pharming in plants offers exciting possibilities to address global access to modern biologics. However, differences in the N-glycosylation pathway including the presence of β(1,2)-xylose and core α(1,3)-fucose can affect activity, potency and ...
Kathrin Göritzer, Melanie Grandits, Clemens Grünwald-Gruber, Rudolf Figl, Sébastien Mercx, Catherine Navarre, Julian K-C. Ma, Audrey Y-H. Teh   +7 more
doaj   +7 more sources

Artificial intelligence-driven systems engineering for next-generation plant-derived biopharmaceuticals [PDF]

Frontiers in Plant Science, 2023
Recombinant biopharmaceuticals including antigens, antibodies, hormones, cytokines, single-chain variable fragments, and peptides have been used as vaccines, diagnostics and therapeutics.
Subramanian Parthiban, Thandarvalli Vijeesh, Thashanamoorthi Gayathri, Balamurugan Shanmugaraj, Ashutosh Sharma, Ramalingam Sathishkumar   +5 more
doaj   +2 more sources

Molecular Pharming: Advances, Applications, and Future Prospects in Biotechnology and Medicine [PDF]

Engineering in Life Sciences
Genetically engineered plants incorporate the use of a novel bioreactor known as molecular pharming, which has a transformative view on the pharmaceutical industry.
Md. Hridoy Ahmed, Md. Mustak Khan, Shishir Dutta, Md. Foyzur Rahman, Mohammad Shariful Islam, Md. Najmul Hosen, Md. Saad Hossain, Md. Aftabur Rahman, Md. Sadman Hasan Sahil, Tanjuma Tasnim Hira, Ifthesum, Ashikur Rahaman, Md. Afser Rabbi, Laila Khaleda   +13 more
doaj   +2 more sources

Recent advances on host plants and expression cassettes' structure and function in plant molecular pharming. [PDF]

BioDrugs, 2014
Plant molecular pharming is a promising system to produce important recombinant proteins such as therapeutic antibodies, pharmaceuticals, enzymes, growth factors, and vaccines. The system provides an interesting alternative method to the direct extraction of proteins from inappropriate source material while offering the possibility to overcome problems
Makhzoum A, Benyammi R, Moustafa K, Trémouillaux-Guiller J.   +3 more
europepmc   +4 more sources

Transcriptomic and metabolomic analysis of carotenoid metabolism and accumulation of carotenoid-derived products in tobacco leaves before and after curing [PDF]

Frontiers in Plant Science
As an important cash crop, tobacco (Nicotiana tabacum L.) is grown to harvest leaves which are cured at elevated temperature before sale. The quality of cured leaves impacts the economic return of growers.
Tao Liu, Na Kong, Jianmin Cao, Gang Chen, Zhichao Deng, Lichao Wen, Zhenbiao Zhang, Cun Guo, Rongrong Wu, Yalun Yang, Wei Li, Yongfeng Guo   +11 more
doaj   +2 more sources

Recent Progress on Vaccines Produced in Transgenic Plants [PDF]

Vaccines, 2022
The development of vaccines from plants has been going on for over two decades now. Vaccine production in plants requires time and a lot of effort. Despite global efforts in plant-made vaccine development, there are still challenges that hinder the ...
Goabaone Gaobotse, Srividhya Venkataraman, Kamogelo M. Mmereke, Khaled Moustafa, Kathleen Hefferon, Abdullah Makhzoum   +5 more
doaj   +2 more sources

Plant-Produced Broadly Neutralizing Influenza Monoclonal Antibody CR9114 Exhibits Activity Against Heterologous Avian Influenza Viruses [PDF]

Vaccines
Background: The continual emergence of antigenically drifted avian influenza viruses poses a persistent threat to global health and underscores the need for broadly protective approaches.
Janejira Jaratsittisin, Win Win Aung, Kaewta Rattanapisit, Pipob Suwanchaikasem, Wayu Matphong, Kanjana Srisutthisamphan, Nanchaya Wanasen, Samaporn Teeravechyan, Waranyoo Phoolcharoen   +8 more
doaj   +2 more sources

Broussonetia papyrifera Pollen Metabolome Insights, Allergenicity, and Dispersal in Response to Climate Change Variables [PDF]

Metabolites
Background/Objectives: Broussonetia papyrifera is a tree-producing allergenic pollen that grows in varied climatic conditions worldwide and causes pollen allergies in susceptible humans. This study aimed to investigate B.
Muhammad Humayun, Saadia Naseem, Richard E. Goodman, Zahid Ali   +3 more
doaj   +2 more sources