Results 71 to 80 of about 503,212 (258)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Integrated nutrient management, soil fertility, and sustainable agriculture: current issues and future challenges [PDF]

The challenge for agriculture over the coming decades will be to meet the world's increasing demand for food in a sustainable way. Declining soil fertility and mismanagement of plant nutrients have made this task more difficult.
Goletti, Francesco, Gruhn, Peter, Yudelman, Montague   +2 more
core  

Organic Food and Health: A new project to study the effects of plant cultivation methods (organic and conventional) on nutritional value, health and reproduction in an animal experiment [PDF]

, 2001
Many consumers believe that food from plants grown under certain conditions, such as organic agriculture, will benefit health more than conventional food.
Andersen, Jens-Otto, Badsberg, Jens Henrik, Brandt, Kirsten, Gundersen, Vagn, Jørgensen, Henry, Larsen, Erik, Lauridsen, Charlotte, Mølgaard, Jens-Peter, Nygaard Larsen, Hanne, Thorup-Kristensen, Kristian   +9 more
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Potassium: A Vital Regulator of Plant Responses and Tolerance to Abiotic Stresses

Agronomy, 2018
Among the plant nutrients, potassium (K) is one of the vital elements required for plant growth and physiology. Potassium is not only a constituent of the plant structure but it also has a regulatory function in several biochemical processes related to ...
Mirza Hasanuzzaman, M. H. M. Borhannuddin Bhuyan, Kamrun Nahar, Md. Shahadat Hossain, Jubayer Al Mahmud, Md. Shahadat Hossen, Abdul Awal Chowdhury Masud, Moumita, Masayuki Fujita   +8 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The Effect of Rhizobium Inoculation on the Nutritional Value of Crops in the Legume–Cereal Intercropping System in Northern Kazakhstan

Agronomy
In this study, the changes in yield, nutrient content, and amino acid levels in legume–cereal grass mixtures were qualitatively evaluated depending on the legume–cereal combination and inoculation with preparations based on Rhizobium.
Marden Baidalin, Akhama Akhet, Saltanat Baidalina, Gulmira Ualiyeva, Sanja Vasiljević   +4 more
doaj   +1 more source

Soil-plant nutrient interactions in two mangrove areas at Southern Brazil

Acta Biológica Colombiana, 2016
Mangrove forests have a simple architecture. They shelter a few number of arboreal species that grow in a saline environment subject to tidal activity. The research objective was to evaluate possible interactions between physical-chemical soil attributes
Ana Paula Lang Martins Madi, Maria Regina Torres Boeger, Carlos Bruno Reissmann, Kelly Geronazzo Martins   +3 more
doaj   +1 more source

Sustainable Management with Mycorrhizae and Phosphate Solubilizing Bacteria for Enhanced Phosphorus Uptake in Calcareous Soils

Agriculture, 2020
Low availability of phosphorus (P) in calcareous soils is a major problem for sustainable improvement in cereals crops yield. A higher amount of calcium in soils precipitates the P, thus making it immobile in soil.
Fazli Wahid, Shah Fahad, Subhan Danish, Muhammad Adnan, Zhen Yue, Shah Saud, Manzer H. Siddiqui, Martin Brtnicky, Tereza Hammerschmiedt, Rahul Datta   +9 more
doaj   +1 more source