Results 51 to 60 of about 137,563 (253)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Real-Time Detection of Rice Growth Phase Transition for Panicle Nitrogen Application Timing Assessment

Agronomy, 2021
Nitrogen (N) topdressing at the early reproductive phase (ER) is beneficial for rice yield. However, the ER overlaps with the late vegetative phase (LV) and is, thus, difficult to be recognized by human observation.
Joon-Keat Lai, Wen-Shin Lin
doaj   +1 more source

Methods in Psychological Research [PDF]

, 2002
Psychologists collect empirical data with various methods for different reasons. These diverse methods have their strengths as well as weaknesses. Nonetheless, it is possible to rank them in terms of different critieria.
Chow, Siu L.
core  

Synthesizing the role of epigenetics in the response and adaptation of species to climate change in freshwater ecosystems [PDF]

, 2018
Freshwater ecosystems are amongst the most threatened ecosystems on Earth. Currently, climate change is one of the most important drivers of freshwater transformation and its effects include changes in the composition, biodiversity and functioning of ...
Allen, Allendorf, Alley, Andrewartha, Anway, Araújo, Ardura, Artemov, Asselman, Asselman, Avise, Baccarelli, Baerwald, Baudo, Bell, Berg, Bernardi, Bernstein, Bianchini, Bind, Bird, Bird, Blake, Bossdorf, Boutin, Brander, Bräutigam, Burggren, Bush, Carpenter, Cañedo-Argüelles, Chown, Clarke, Corcoran, Crozier, Dai, Dallas, Daxinger, Denissenko, Detrich, Dudgeon, Durance, Eros, Fasola, Feil, Fenoglio, Foley, Friberg, Fulneček, Garg, Gienapp, Glastad, Goldberg, Gonçalves, Guillette, Hanson, Harris, Heino, Henry, Hering, Hernando-Herraez, Ho, Hoegh-Guldberg, Hoffmann, Hu, Jabbari, Jablonka, Jackson, Jackson, Jaenisch, Janssens, Jiang, Karell, Karr, Kefford, Keller, Kelly, Klimenko, Klironomos, Kouzarides, Kronholm, Kronholm, Kumar, Kurdyukov, Laland, Laland, Lan, Latta, Leung, Lighten, Liu, Loureiro, Loureiro, Lämke, Manjrekar, Markovic, Martinez-Sales, Martínez-Jerónimo, Matthews, Mattick, Meissner, Mendizabal, Merilä, Merilä, Michener, Mimura, Minshull, Mirbahai, Mohseni, Moore, Mudbhary, Mulholland, Munday, Nabel, Nielsen, Norouzitallab, Parichy, Park, Pestana, Peterson, Pigliucci, Pigliucci, Pu, Qu, Rey, Ribeiro, Rinn, Ryan, Sarda, Scheiner, Scheiner, Schindler, Schrey, Shaw, Shea, Solan, Srinageshwar, Stief, Sun, Suter, Suzuki, Szabo, Sáez, Urich, Vandegehuchte, Vandegehuchte, Vannier, Varriale, Varriale, Varriale, Venâncio, Verhoeven, Verhoeven, Vogt, Vogt, Vogt, Wang, Wang, Weider, Weinberg, Weyrich, Willbanks, Williams, Wong, Woodward, Woodward, WWAP   +166 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Factors affecting the production of sugarcane yield and sucrose accumulation: suggested potential biological solutions

Frontiers in Plant Science
Environmental stresses are the main constraints on agricultural productivity and food security worldwide. This issue is worsened by abrupt and severe changes in global climate.
Faisal Mehdi, Faisal Mehdi, Zhengying Cao, Zhengying Cao, Shuzhen Zhang, Shuzhen Zhang, Yimei Gan, Yimei Gan, Wenwei Cai, Wenwei Cai, Lishun Peng, Lishun Peng, Yuanli Wu, Yuanli Wu, Wenzhi Wang, Wenzhi Wang, Benpeng Yang, Benpeng Yang   +17 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

The Effects of Climate Changes on the Phenology of Some Chokeberry (Aronia melanocarpa) Cultivars

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Horticulture
Climate change represents a significant challenge characterized by long-term increases in global temperatures, which subsequently alter plant phenology and growth cycles.
Anca Maria CHIOREAN, Zsolt JAKAB- ILYEFALVI, Smaranda ROŞU-MAREŞ, Georgeta GUZU, Claudiu MOLDOVAN, Ioan ZAGRAI, Adrian ASĂNICĂ, Mirela Irina CORDEA   +7 more
doaj   +1 more source

Neurotoxicity [PDF]

, 2014
Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust, Creeley, Feldman, Grandjean, Herken, Panzica, Parent, Pessah, Rice, Román, Spencer, Spencer, Tu, Vinken, Yasui, Zawia   +15 more
core   +2 more sources