Results 141 to 150 of about 4,262,374 (335)
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
"Chamber #8" - a holistic approach of high-throughput non-destructive assessment of plant roots. [PDF]
Front Plant Sci, 2023 Claussen J +3 more
europepmc +1 more source
III.—Supplementary note to a memoir on the power ascribed to the roots of plants of rejecting poisonous or abnormal substances presented to them [PDF]
Charles Daubeny
openalex +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
INVESTIGATIONS ON THE ROOT HABITS OF PLANTS
American Journal of Botany, 1925 Ten years ago, while studying the vegetation of semi-arid eastern Washington, interest in root studies was aroused because of the extensive root systems of the native species. Balsamorrhiza sagittata, the first plant excavated, is representative. The strong tap root reaches a depth of six feet, and very numerous branches run laterally to distances of ...
openaire +3 more sources
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
The worldwide allometric relationship in anatomical structures for plant roots. [PDF]
Plant Divers, 2023 Zhang Y +5 more
europepmc +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Super-resolution expansion microscopy in plant roots. [PDF]
Plant CellGallei M +14 more
europepmc +2 more sources