Results 31 to 40 of about 22,314 (260)

Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8

Journal of Lipid Research, 2002
The plasma concentrations of cholesterol precursor sterols and plant sterols vary over a 5- to 10-fold range among normolipidemic individuals, and provide indices of the relative rates of cholesterol synthesis and fractional absorption.
Knut E. Berge, Klaus von Bergmann, Dieter Lutjohann, Rudy Guerra, Scott M. Grundy, Helen H. Hobbs, Jonathan C. Cohen   +6 more
doaj   +1 more source

Accumulation of cholesterol precursors and plant sterols in human stenotic aortic valves

Journal of Lipid Research, 2008
The pathogenesis of aortic valve stenosis (AS) is characterized by the accumulation of LDL-derived cholesterol in the diseased valves. Since LDL particles also contain plant sterols, we investigated whether plant sterols accumulate in aortic valve ...
Satu Helske, Tatu Miettinen, Helena Gylling, Mikko Mäyränpää, Jyri Lommi, Heikki Turto, Kalervo Werkkala, Markku Kupari, Petri T. Kovanen   +8 more
doaj   +1 more source

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Feedback regulation of cholesterol biosynthesis in rhesus monkeys with variable hypercholesterolemic response to dietary cholesterol1

Journal of Lipid Research, 1981
To test the hypothesis that high-responding rhesus monkeys should have a greater degree of feedback inhibition of hepatic cholesterol biosynthesis than the low-responding monkeys because the former group absorbs a higher percentage of cholesterol than ...
A K Bhattacharyya, D A Eggen
doaj   +1 more source

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

Scientific Opinion on the substantiation of a health claim related to 3 g/day plant sterols/stanols and lowering blood LDL‐cholesterol and reduced risk of (coronary) heart disease pursuant to Article 19 of Regulation (EC) No 1924/2006

EFSA Journal, 2012
Following an application from Unilever PLC and Unilever NV, submitted pursuant to Article 19 of Regulation (EC) No 1924/2006 via the Competent Authority of the United Kingdom, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver ...
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)
doaj   +1 more source

Lethal atherosclerosis associated with abnormal plasma and tissue sterol composition in sitosterolemia with xanthomatosis.

Journal of Lipid Research, 1985
Tissue sterol composition was determined in an 18-year-old male with sitosterolemia with xanthomatosis who died suddenly and whose coronary and aortic vessels showed extensive atherosclerosis and, for comparison, in an 18-year-old male with minimal ...
G Salen, I Horak, M Rothkopf, J L Cohen, J Speck, G S Tint, V Shore, B Dayal, T Chen, S Shefer   +9 more
doaj   +1 more source

Fate of intravenously administered squalene and plant sterols in human subjects

Journal of Lipid Research, 2001
We have studied metabolism of plant sterols and squalene administered intravenously in the form of lipid emulsion mimicking chylomicrons (CM). The CM-like lipid emulsion was prepared by dissolving squalene in commercially available Intralipid®.
Heikki Relas, Helena Gylling, Tatu A. Miettinen   +2 more
doaj   +1 more source

Sterols in the small intestine of the rat, guinea pig, and rabbit

Journal of Lipid Research, 1971
The sterol content and composition of the small intestinal mucosa has been studied in the rat, guinea pig, and rabbit. In the three species, noncholesterol sterols formed a large proportion of the total sterol content. In the rat, the contribution due to
NEIL McINTYRE, KATHARINA KIRSCH, J.C. ORR, K.J. ISSELBACHER   +3 more
doaj   +1 more source

Data on structural analysis of cholesterol binding and sterol selectivity by ABCG5/G8

Data in Brief, 2022
ATP-Binding cassette subfamily G (ABCG) sterol transporters maintain whole body endogenous and exogenous sterol homeostasis. A substantial portion of exogenous sterols are undigestible phytosterols (plant sterols), which can introduce complications when ...
Danny Farhat, Fatemeh Rezaei, Jyh-Yeuan Lee   +2 more
doaj   +1 more source