Results 121 to 130 of about 62,237 (305)

Research Progress on the Mechanism of the Antitumor Effects of Cannabidiol

Molecules
Cannabidiol (CBD), a non-psychoactive ingredient extracted from the hemp plant, has shown therapeutic effects in a variety of diseases, including anxiety, nervous system disorders, inflammation, and tumors.
Li Ma, Mengke Liu, Chuntong Liu, Huachang Zhang, Shude Yang, Jing An, Guiwu Qu, Shuling Song, Qizhi Cao   +8 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Solitary metastatic tumors to the pancreas: a case report and review of the literature

, 1996
Secondary pancreatic tumors should be considered in those patients who present with a solitary pancreatic mass and who have had a previous nonpancreatic malignancy.
Barkin, J S, Robbins, 2nd, E G, Franceschi, D   +2 more
core  

Common Diagnostic Challenges in Genitourinary Mesenchymal Tumors: A Practical Approach

Mesenchymal neoplasms within the genitourinary tract include a wide spectrum of tumors, ranging from benign to malignant, and tumors of uncertain malignant potential.
Kryvenko, Oleksandr N., Velez Torres, Jaylou M.   +1 more
core   +1 more source

Proteome and Metabolome Alterations in Radish (Raphanus sativus L.) Seedlings Induced by Inoculation with Agrobacterium tumefaciens

Biomolecules
Infection of higher plants with agrobacteria (Agrobacterium tumefaciens) represents one of the most comprehensively characterized examples of plant–microbial interactions. Incorporation of the bacterial transfer DNA (T-DNA) in the plant genome results in
Nadezhda Frolova, Daria Gorbach, Christian Ihling, Tatiana Bilova, Anastasia Orlova, Elena Lukasheva, Ksenia Fedoseeva, Irina Dodueva, Lyudmila A. Lutova, Andrej Frolov   +9 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

New or unusual dermatopathology tumors: a review

, 2011
As experience is acquired, there is a constant evolution in both terminology and understanding of various relatively newly described tumors in the realm of dermatopathology. Several mesenchymal tumors of the lower extremity have undergone various changes
Terry L. Barrett, Montgomery, Elizabeth A., Elizabeth A. Montgomery, Barrett, Terry L., Marc Roy Lewin, Lewin, Marc Roy   +5 more
core   +1 more source

Plant-derived extracellular vesicles as a novel tumor-targeting delivery system for cancer treatment

Frontiers in Cell and Developmental Biology
Extracellular vesicles (EVs) are vital mediators of intercellular communication, helping to transfer bioactive molecules to target cells and demonstrating significant potential in antitumor therapy.
Hanjin Wu, Mengya Shi, Liwei Meng, Jie Qiu, Yuancong Jiang, Da Qian, Fengqing Shen   +6 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Androgen and vitamin D receptor expression in archival human breast tumors

, 2004
Background The present study was undertaken for quantitation of androgen (AR) and vitamin D (VDR) receptor expression in human male and female breast tumors by flow cytometry.
Krishan, Awtar, Poonam Arya, Arya, Poonam, Escoffery, Carlos T, Awtar Krishan, Parvin Ganjei‐Azar, Nadji, Mehrdad, Mehrdad Nadji, Carlos T. Escoffery, Shirley, Suzanne E, Suzanne E. Shirley, Ganjei‐Azar, Parvin   +11 more
core   +1 more source