Results 91 to 100 of about 58,273 (309)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Potential impact of genetically modified plants on biodiversity
, 2018 Currently, the introduction ofgenetically modified organisms (GMOs) has raised some concerns and the plantingareas of these organisms continue to expand every year. In recent years, it isforbidden to cultivate food and feeds produced with genetic engineeringtechnology in Turkey.
ARVAS, Yunus Emre, KAYA, Yılmaz
openaire +2 more sources
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Commentary Safety assessment of genetically modified plants with deliberately altered composition
, 2014 novel traits, crop and food composition, plant biotechnology, risk assessment, food safety. Summary The development and marketing of ‘novel ’ genetically modified (GM) crops in which composition has been deliberately altered poses a challenge to the ...
Gimson, A. +10 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
The importance of risk assessment of genetically modified plants
Current Opinion in Biotechnology, 2011 Öz bulunamadı.
openaire +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
, 2006 This paper discusses the implications of using genetically modified crops to biomanufacture pharmaceuticals and industrial compounds from the perspective of their co-existence with conventional agriculture. Such plant-made pharmaceuticals and plantmade
core
Guidance on the agronomic and phenotypic characterisation of genetically modified plants
EFSA Journal, 2015 This document provides guidance for the agronomic and phenotypic characterisation of genetically modified (GM) plants and clarifies the EFSA GMO Panel's view on how agronomic and phenotypic data support the risk assessment of GM plants.
EFSA Panel on Genetically Modified Organisms (GMO)
doaj +1 more source
Increase of efficiency of the photosynthetic device of plants by gene updating.
Plant Varieties Studying and Protection, 2011 In the information advantages of plants of agricultural crops with photosynthesis C4 before plants of type C3 are shined. By means of genetically-modified designs uses introductions such C4 a metabolism, or its part the estimation of possibilities is ...
О. І. Рудник-Іващенко
doaj +1 more source