Results 111 to 120 of about 3,336,285 (308)
, 2011 This opinion provides guidance in the area of comparators taking into account the requirements for the molecular characterisation, the food and feed and the environmental risk assessments.
EFSA Panel on Genetically Modified Organisms (GMO)
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Acta Scientiarum Polonorum: Hortorum Cultus, 2013 Green biotechnology plays an important role in the modern agriculture. Recent progress in molecular biology and genetic engineering provides an opportunity of obtaining transgenic plants with improved characteristics, such as yield parameters ...
Magda Zapalska, Krzysztof Kowalczyk
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
CONSUMER ACCEPTANCE OF FOOD BIOTECHNOLOGY: WILLINGNESS TO BUY GENETICALLY MODIFIED FOOD PRODUCTS [PDF]
Biotechnology is often viewed as the defining technology for the future of food and agriculture with the potential to deliver a wide range of economic and health benefits.
Onyango, Benjamin M. +4 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Developing a good practice for the review of evidence relevant to GMO risk assessment
, 2013 Recent controversies over peer-reviewed papers on potential impacts of genetically modified organisms underline the necessity for an explicit, transparent and unbiased reviewing of published results. Evidence synthesis approaches represent powerful tools
Kohl, Christian +12 more
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Impact of genetically modified organisms on meat quality
Open Veterinary JournalA unique class of gene biotechnology known as genetic modification modifies the genetic makeup of living things like microbes, plants, and animals. Several possible advantages and hazards associated with gene biotechnology. Due to increased food demands
Muntaha Ghazi Hasan
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
An Analysis of McLean County, Illinois Farmers' Perceptions of Genetically Modified Crops [PDF]
McLean County, Illinois farmers were surveyed in order to explore and analyze their perceptions of genetically modified crops and their genetically modified cropping decisions.
Chimmiri, Nagesh +2 more
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