Results 111 to 120 of about 575,333 (346)

Vulnerable atherosclerotic plaques

Medical academic journal, 2009
The initial pathogenesis moment in development of an acute sharp coronary thrombosis is break, so-called vulnerable atherosclerotic plaque. The combination of an inflammation, distraction a collagenic skeleton, refind tire covers plaque and a spasm of arteries leads to break of a surface plaque therefore process thrombogenesis is started, leading ...
E J Naumova, E S Naumov
openaire   +1 more source

KLF4 Dependent Phenotypic Modulation of SMCs Plays a Key Role in Atherosclerotic Plaque Pathogenesis

Nature Medicine, 2015
Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods for clearly identifying each of these cell types. Here,
Laura S. Shankman, Delphine Gomez, O. Cherepanova, Morgan D. Salmon, G. F. Alencar, Ryan M. Haskins, P. Swiatlowska, Alexandra A. C. Newman, Elizabeth S. Greene, A. Straub, B. Isakson, G. Randolph, G. Owens   +12 more
semanticscholar   +1 more source

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Chromosomal alterations in atherosclerotic plaques

Atherosclerosis, 2001
Alterations of chromosomes 7 and 11 have been involved in the progression of atherosclerosis. Twenty-three carotid endarterectomy specimens were studied for the presence of alterations in chromosomes 7 and 11, and fibroblastic growth factor-3 (FGF-3) gene amplification.
L. Matturri, A. Cazzullo, P. Turconi, A.M. Lavezzi, P. L. Vandone, L. Gabrielli, G. Fernández Alonso, D. Grana, J. Milei   +8 more
openaire   +3 more sources

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Angiogenesis within atherosclerotic plaques: Mechanical regulation, molecular mechanism and clinical diagnosis

Mechanobiology in Medicine
Atherosclerosis (AS) is a disease characterized by focal cholesterol accumulation and insoluble inflammation in arterial intima, leading to the formation of an atherosclerotic plaque consisting of lipids, cells, and fibrous matrix. The presence of plaque
Hanxiao Chen, Chengxiu Peng, Fei Fang, Yuhao Li, Xiaran Liu, Ying Hu, Guixue Wang, Xiaoheng Liu, Yang Shen   +8 more
doaj   +1 more source

Exploration of the atherosclerotic plaque

Biomedicine & Pharmacotherapy, 1990
During the past 3 decades we have achieved a better understanding of the atherosclerotic process. It has been described as a series of changes in the intima of arteries consisting of the focal accumulation of lipids, complex carbohydrates, blood and blood products, fibrous tissues, and calcium that are also associated with changes in the media.
J H, Ip, V, Fuster, J H, Chesebro
openaire   +2 more sources

Angiotensin II as an Inducer of Atherosclerosis: Evidence from Mouse Studies [PDF]

, 2013
Mechanisms responsible for atherosclerotic plaque development, destabilization, and rupture are still largely unknown. Angiotensin II, the main bioactive peptide of renin angiotensin system, has been shown to be critically involved in the pathogenesis of
Mazzolai, L., Pellegrin, M.
core   +1 more source

Mechanically Robust Biodegradable Stents With Theragenerative Vascular Responses via Combined 3D Printing and Janus Nanoengineering

Advanced Science, EarlyView.
This work introduces a theragenerative 3D‐printed biodegradable stent with Janus nanoarchitecture for spatially controlled vascular healing. A luminal tantalum ion–implanted surface accelerates endothelialization and hemocompatibility, while an abluminal sirolimus/poly‐L‐lactic acid–tantalum layer provides sustained drug release and suppresses smooth ...
Jong Hwa Seo, Dong‐Sung Won, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Chan Ho Moon, Ji Won Kim, Yubeen Park, Minho Kang, Dong Yun Lee, Donghyun Lim, Kisuk Yang, Gi Doo Cha, Soo‐Hong Lee, Tae‐Sik Jang, Seokbeom Kim, Jun‐Kyu Park, Jung‐Hoon Park, Hyun‐Do Jung   +19 more
wiley   +1 more source

IVUS-based histology of atherosclerotic plaques: improving longitudinal resolution [PDF]

, 2010
Although Virtual Histology (VH) is the in-vivo gold standard for atherosclerosis plaque characterization in IVUS images, it suffers from a poor longitudinal resolution due to ECG-gating. In this paper, we propose an image- based approach to overcome this
Navab, Nassir, Pauly, Olivier, Setarehdan, S.Kamaledin, Taki, Arash, Unal, Gozde, Ünal, Gözde   +5 more
core   +1 more source