Results 231 to 240 of about 503,732 (331)

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

CD137 Signaling Modulates Vein Graft Atherosclerosis by Driving T-Cell Activation and Regulating Intraplaque Angiogenesis. [PDF]

JACC Basic Transl Sci
de Jong A, Sluiter TJ, Peters HAB, Lamens A, Jukema JW, Arens R, Quax PHA, de Vries MR.   +7 more
europepmc   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Anti-Atherogenic Mechanisms and Therapies. [PDF]

Curr Atheroscler Rep
Hudson A, Igiehon OO, Woolard MD, Yurdagul A.   +3 more
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

How lactate and lactylation shape the immunity system in atherosclerosis (Review). [PDF]

Int J Mol Med
Xiong Y, Zhou J, Wang J, Huang H.
europepmc   +1 more source

Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases

Cell Proliferation, EarlyView.
HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang, Yue‐Yue Wang, Ri Wen, Tie‐Ning Zhang, Ni Yang   +4 more
wiley   +1 more source

Exercise in atherosclerosis: its beneficial effects and underlying mechanism. [PDF]

Front Cell Dev Biol
Yin MT, Guo L.
europepmc   +1 more source

miRNAs in atherosclerotic plaque initiation, progression, and rupture.

Trends in Molecular Medicine, 2015
Ioannis Andreou, Xinghui Sun, P. Stone, E. Edelman, M. W. Feinberg   +4 more
semanticscholar   +1 more source

High‐intensity statin therapy is associated with reduced coronary inflammation on CT in patients with type 2 diabetes mellitus

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Pericoronary adipose tissue (PCAT) attenuation, assessed by coronary computed tomography angiography (CCTA), is a biomarker of coronary inflammation. Mean PCAT attenuation ≥ −70.5 Hounsfield Units (HU) corresponds to elevated inflammation and a higher future risk of myocardial infarction.
Bryan Wu, Koen Nieman, Ryan Sandoval
wiley   +1 more source