Results 111 to 120 of about 1,105,082 (410)

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Visual pedagogy and probiotics for hearing impaired children: A pilot study

Journal of Indian Society of Pedodontics and Preventive Dentistry, 2017
Context: Oral health care for children with special needs remains largely unmet. It is important that we should focus on preventive strategies for special children to help curtail and prevent oral diseases.
Amrita Sujlana, Ruchika Goyal, Parampreet Pannu, Shireen Opal, Palki Bansal   +4 more
doaj   +1 more source

Combining Biomarkers and Imaging for Short‐Term Assessment of Cardiovascular Disease Risk in Apparently Healthy Adults

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Current strategies for cardiovascular disease (CVD) risk assessment focus on 10‐year or longer timeframes. Shorter‐term CVD risk is also clinically relevant, particularly for high‐risk occupations, but is under‐investigated.
Maria Odette Gore, Colby R. Ayers, Amit Khera, Christopher R. deFilippi, Thomas J. Wang, Stephen L. Seliger, Vijay Nambi, Elizabeth Selvin, Jarett D. Berry, W. Gregory Hundley, Matthew Budoff, Philip Greenland, Mark H. Drazner, Christie M. Ballantyne, Benjamin D. Levine, James A. de Lemos   +15 more
doaj   +1 more source

Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability

Nature Communications, 2016
Endothelial to mesenchymal transition (EndMT) plays a major role during development, and also contributes to several adult cardiovascular diseases. Importantly, mesenchymal cells including fibroblasts are prominent in atherosclerosis, with key functions ...
S. Evrard, L. Lecce, K. Michelis, A. Nomura-Kitabayashi, Gaurav Pandey, K. Purushothaman, Valentina d’Escamard, Jennifer R. Li, Lahouaria Hadri, K. Fujitani, P. Moreno, L. Bénard, P. Rimmelé, A. Cohain, B. Mecham, G. Randolph, E. Nabel, R. Hajjar, V. Fuster, M. Boehm, J. Kovacic   +20 more
semanticscholar   +1 more source

The role of p53 in atherosclerosis [PDF]

, 2006
Although the role of the tumour suppressor gene p53 is well known in cancer, recent studies have highlighted a fundamental role for p53 in regulating cells in the advanced atherosclerotic plaque, the major cause of heart attacks and stroke. In particular,
Bennett, M., Mercer, J.R.
core   +1 more source

Modelling Atherosclerotic Plaque Cap Mechanics: Microcalcifications Reduce Mechanical Properties in Mesenchymal Stromal Cell‐Based Model

Advanced Biology, EarlyView.
This study develops a tissue‐engineered model of the atherosclerotic cap using human mesenchymal stromal cells (MSCs). After 2 weeks of culture to produce a collagenous matrix, a mineralizing medium induces microcalcifications over 4 weeks. These constructs, imaged with second harmonic generation microscopy, lead to reduced ultimate stress at rupture ...
Imke L. Jansen, Deniz Şahin, Frank J.H. Gijsen, Eric Farrell, Kim van der Heiden   +4 more
wiley   +1 more source

Intracranial Atherosclerosis: Current Understanding and Perspectives [PDF]

Journal of Stroke, 2014
The importance of intracranial atherosclerotic disease (ICAD) as a cause of stroke is underscored as compared to that of extracranial carotid stenosis and nonvalvular atrial fibrillation.
Oh Young Bang
doaj   +1 more source

Coronary artery plaque characteristics and treatment with biologic therapy in severe psoriasis: results from a prospective observational study

Cardiovascular Research, 2019
AIMS The use of biologic therapy has increased over the past decade well beyond primary autoimmune diseases. Indeed, a recent trial using an anti-IL-1beta antibody reduced second myocardial infarction (MI) in those who have had MI. Psoriasis is a chronic
Youssef Elnabawi, A. Dey, Aditya Goyal, Jacob W. Groenendyk, Jonathan H. Chung, A. Belur, J. Rodante, Charlotte L. Harrington, H. Teague, Y. Baumer, A. Keel, M. Playford, V. Sandfort, Marcus Y. Chen, B. Lockshin, J. Gelfand, D. Bluemke, N. Mehta   +17 more
semanticscholar   +1 more source

Imaging the Vulnerable Plaque

Journal of the American College of Cardiology, 2011
Cardiovascular diseases are still the primary causes of mortality in the United States and in Western Europe. Arterial thrombosis is triggered by a ruptured atherosclerotic plaque and precipitates an acute vascular event, which is responsible for the high mortality rate.
Vancraeynest, D, Pasquet, A, Roelants, V, Gerber, Bernhard L, Vanoverschelde, Jean-Louis J   +4 more
openaire   +4 more sources

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source