Results 101 to 110 of about 29,718 (289)

Scalable, semi-automated fluorescence reduction neutralization assay for qualitative assessment of Ebola virus-neutralizing antibodies in human clinical samples.

PLoS ONE, 2019
Antibody titers against a viral pathogen are typically measured using an antigen binding assay, such as an enzyme-linked immunosorbent assay (ELISA), which only measures the ability of antibodies to identify a viral antigen of interest.
Elena N Postnikova, James Pettitt, Collin J Van Ryn, Michael R Holbrook, Laura Bollinger, Shuǐqìng Yú, Yíngyún Caì, Janie Liang, Michael C Sneller, Peter B Jahrling, Lisa E Hensley, Jens H Kuhn, Mosoka P Fallah, Richard S Bennett, Cavan Reilly   +14 more
doaj   +1 more source

EGR Proteins Mediate Interferon‐Independent Anti‐HSV‐1 Responses Through Viral and Host Targets

Advanced Science, EarlyView.
Early antiviral responses are typically mediated by interferons. However, during HSV‐1 infection, host early growth response (Egr) genes, which are not interferon‐stimulated genes, are quickly induced by viral protein ICP0. EGR proteins, in turn, suppress viral lytic infection by activating viral latency‐associated (LAT) and host immune regulatory ...
Shuaishuai Wang, Fujun Hou, Xunuo Jin, Yuhang Xiang, Dongli Pan   +4 more
wiley   +1 more source

The Zika outbreak of the 21st century. [PDF]

, 2016
The Zika virus outbreak has captivated the attention of the global audience and information has spread rapidly and wildly through the internet and other media channels.
Ansari, Aftab, Chang, Christopher, Gershwin, M Eric, Ortiz, Kristina   +3 more
core   +1 more source

Serological evidence of West Nile virus infection in the horse population of northern Serbia

Journal of Infection in Developing Countries, 2014
Introduction: This study was conducted to evaluate the seroprevalence of West Nile virus (WNV) in the horse population of northern Serbia. Furthermore, it aimed to provide insight and an updated overview on the circulation of this re-emerging pathogen in
Strahinja Medić, Rene van den Hoven, Tamaš Petrović, Diana Lupulović, Norbert Nowotny   +4 more
doaj   +1 more source

Plaque reduction neutralization antibody test does not accurately predict protection against dengue infection in Ratchaburi cohort, Thailand [PDF]

Virology Journal, 2014
يعد اختبار تحييد تقليل البلاك (PRNT) حاليًا أفضل الطرق وأكثرها قبولًا لقياس الأجسام المضادة المعادلة للفيروس والأجسام المضادة الواقية لفيروس حمى الضنك، وفي تقييم التوليد المناعي للقاح حمى الضنك. ومع ذلك، فإن العلاقة بين وجود الجسم المضاد المعادل لحمى الضنك والحماية من العدوى ليست مطلقة.
Chukiat Sirivichayakul, Arunee Sabchareon, Kriengsak Limkittikul, Sutee Yoksan   +3 more
openaire   +2 more sources

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

Advanced Science, EarlyView.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang, Tianxin Ma, Yujiao He, Qinming Li, Kailin Mai, Minying Mo, Chenyang Cao, Jiahui Li, Pei Feng, Jiaojiao Peng, Jing Sun, Weiqi Pan, Zifeng Yang, Ling Chen   +13 more
wiley   +1 more source

Drivers of MERS-CoV transmission: what do we know? [PDF]

, 2016
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Tawfiq, Jaffar A., Memish, Ziad A.
core   +1 more source

Use of Sindbis/Eastern Equine Encephalitis Chimeric Viruses in Plaque Reduction Neutralization Tests for Arboviral Disease Diagnostics [PDF]

Clinical and Vaccine Immunology, 2011
ABSTRACTEastern equine encephalitis virus (EEEV) is a highly virulent, mosquito-borne alphavirus that causes severe and often fatal neurological disease in humans and horses in eastern North American, the Caribbean, and Mexico and throughout Central and South America.
B W, Johnson, O, Kosoy, E, Wang, M, Delorey, B, Russell, R A, Bowen, S C, Weaver   +6 more
openaire   +2 more sources

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source