Results 201 to 210 of about 29,718 (289)

Efficacy, Safety and Biological Characteristics of Formulation Based on Essential Oil Against Co‐Infections of Herpes Simplex Virus‐1 and Candida albicans

open access: yesMicrobiologyOpen, Volume 15, Issue 1, February 2026.
Essential oils with anti‐HSV‐1 activity were identified through literature review and tested against Candida to develop a formulation for co‐infections. The blend was assessed for anti‐inflammatory properties, allergenic potential via standardized BAT, and overall antiviral efficacy.
Maura Di Vito   +11 more
wiley   +1 more source

Nanomedicine Strategies Against Biofilm‐Associated Infections: Advances, Challenges, and Translational Barriers

open access: yesMicrobiologyOpen, Volume 15, Issue 1, February 2026.
Explore the key challenges and limitations in nanomedicine for biofilm treatment, from drug loading efficiency to antimicrobial resistance. ABSTRACT Antimicrobial resistance continues to rise globally, with biofilm‐associated infections intensifying the clinical burden through persistent tolerance to antibiotics and evasion of immune responses ...
Husni Farah   +8 more
wiley   +1 more source

Construction of Reverse Genetics System for Feline Calicivirus FCV‐BJ616 and Proteomic Analysis

open access: yesMicrobiologyOpen, Volume 15, Issue 1, February 2026.
This study successfully isolated the FCV‐BJ616 strain derived from cats and established a reverse genetics system. In vivo experiments showed that rFCV‐BJ616 exhibits wild‐type virulence, leading to high fever, weight loss, and multi‐organ lesions in infected cats. Proteomic analysis indicated that both rFCV‐BJ616 and FCV‐BJ616 share similar regulatory
Chunmei Xu   +9 more
wiley   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo   +11 more
wiley   +1 more source

Progress in RNA‐Targeted Therapeutics for Human Diseases

open access: yesMedComm, Volume 7, Issue 2, February 2026.
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang   +10 more
wiley   +1 more source

An mRNA Vaccine Based on Antigens From Conserved Regions of Monkeypox Virus A35R and M1R With a Dimer‐Like Conformation Confers Protection Against Both Monkeypox Virus and Vaccinia Virus Infections in Mice

open access: yesMedComm, Volume 7, Issue 2, February 2026.
We developed four candidate mRNA vaccine antigens based on conserved sequences of MPXV A35R and M1R proteins. Our findings demonstrate that the MV2 vaccine possesses favorable immunogenicity and prophylactic potential against MPXV and VACV infections, positioning it as a promising clinical candidate for MPXV prevention.
Cong Tang   +14 more
wiley   +1 more source

Brain Amyloid Plaque Levels Affect Clinical Progression in Alzheimer Disease: Assessment of Amyloid PET and Change in CDR‐SB Utilizing Semi‐Mechanistic Model

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Lecanemab is a humanized IgG1 monoclonal antibody binding with high affinity to protofibrils of amyloid‐beta (Aβ) protein. In clinical studies, lecanemab has been shown to reduce amyloid markers in early symptomatic Alzheimer's disease and slow decline on clinical endpoints of cognition and function.
Pratik Bhagunde   +7 more
wiley   +1 more source

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