Results 71 to 80 of about 583,340 (301)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Physical properties of natural and processed water using dielectric barrier and gliding arc discharge [PDF]

AIP Advances
In this study, we produced an atmospheric pressure dielectric barrier and a gliding arc plasma jet and explored their impact on various physical properties of different natural and processed waters. The investigation was carried out under varying volumes,
Roshan Chalise, Om Shree Rijal, Dipak Oli, Krishna Regmi, Sadip Nepal, Raju Khanal   +5 more
doaj   +1 more source

Oxidation of clofibric acid in aqueous solution using a non-thermal plasma discharge or gamma radiation

, 2017
In this work, we study degradation of clofibric acid (CFA) in aqueous solution using either ionizing radiation from a $^{60}$Co source or a non-thermal plasma produced by discharges in the air above the solution.
Ceriani, Elisa, Madureira, Joana, Margaça, Fernanda M. A., Marotta, Ester, Melo, Rita, Paradisi, Cristina, Pinhão, Nuno, Verde, Sandra Cabo   +7 more
core   +1 more source

Visible light assisted organosilane assembly on mesoporous silicon films and particles [PDF]

, 2019
Porous silicon (PSi) is a versatile matrix with tailorable surface reactivity, which allows the processing of a range of multifunctional films and particles. The biomedical applications of PSi often require a surface capping with organic functionalities.
Ceccone, Giacomo, Noval, Alvaro Muñoz, Rodriguez, Chloé, Silván, Miguel Manso, Torres-Costa, Vicente   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Direct and Indirect Bactericidal Effects of Cold Atmospheric-Pressure Microplasma and Plasma Jet

Molecules, 2021
The direct and indirect bactericidal effects of dielectric barrier discharge (DBD) cold atmospheric-pressure microplasma in an air and plasma jet generated in an argon-oxygen gas mixture was investigated on Staphylococcus aureus and Cutibacterium acnes ...
Ahmad Guji Yahaya, Tomohiro Okuyama, Jaroslav Kristof, Marius Gabriel Blajan, Kazuo Shimizu   +4 more
doaj   +1 more source

Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features [PDF]

, 2015
Internal levels of selected endocrine disruptors (EDs) (i.e., perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), di-2-ethylhexyl-phthalate (DEHP), mono-(2-ethylhexyl)-phthalate (MEHP), and bisphenol A (BPA)) were analyzed in blood/serum of ...
Bergamasco B, Bordi G, Busani L, Caserta D, Ciardo F, Focardi S, Guerranti C, La Rocca C, Mancini FR, Mantovani A, Marci R, Moscarini M, Perra G, Stecca L, Tait S   +14 more
core   +2 more sources

Mycotoxin Decontamination of Foods Using Nonthermal Plasma and Plasma-Activated Water

, 2022
Mycotoxins are food safety and public health concerns due to their widespread contamination in agricultural products and adverse health effects on humans. Several decontamination techniques, including physical-, chemical-, and thermal-based treatments, are employed to minimize the levels of mycotoxins in food.
Hsiu-Ling, Chen,, D., Arcega, Rachelle, Samuel, Herianto,, Chih-Yao, Hou,, Chia-Min, Lin,   +4 more
openaire   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Characterization of three vasopressin receptor 2 variants: an apparent polymorphism (V266A) and two loss-of-function mutations (R181C and M311V). [PDF]

, 2013
Arginine vasopressin (AVP) is released from the posterior pituitary and controls water homeostasis. AVP binding to vasopressin V2 receptors (V2Rs) located on kidney collecting duct epithelial cells triggers activation of Gs proteins, leading to increased
Armstrong, Stephen P, Ayoub, Mohammed Akli, Feldman, Brian J, Pfleger, Kevin DG, Seeber, Ruth M   +4 more
core   +2 more sources