Results 211 to 220 of about 636,644 (329)

Decellularized Extracellular Matrix Scaffolds to Engineer the Dormant Landscape of Microscopic Colorectal Cancer Liver Metastasis

Advanced Healthcare Materials, EarlyView.
Decellularized liver extracellular matrix scaffolds provide a platform to study dormant liver‐metastatic colorectal cancer. They induce reversible dormancy, in combination with nutrient depletion and low dose chemotherapy, through cell cycle arrest and chemotherapy resistance.
Sabrina N. VandenHeuvel, Lucia L. Nash, Abigail J. Clevenger, Claudia A. Collier, Oscar R. Benavides, Sanjana Roy, Brinlee Goggans, Aelita Salikhova, Anvitha Tharakesh, Svasti Haricharan, Amber N. Stratman, Scott Kopetz, Alex J. Walsh, Shreya A. Raghavan   +13 more
wiley   +1 more source

Metallofullerenol Sc3N@C80(OH)18: A New Generation Radioprotector Protecting Human Erythrocytes Against Multiple Biochemical Damage Modes Upon Gamma Irradiation, Identifying It as a Scavenger of Short‐ and Long‐Lived Radicals

Advanced Healthcare Materials, EarlyView.
Metallofullerenol Sc3N@C80(OH)18 demonstrates strong radioprotective properties as a scavenger of both short‐ and long‐lived radicals. The study reveals protection of human erythrocytes from γ‐radiation–induced biochemical damage via post‐irradiation removal of primary and secondary reactive oxidants, supported by pulse radiolysis kinetics.
Jacek Grebowski, Maciej Studzian, Szymon Lekki‐Porebski, Anna Konarska, Marian Wolszczak, Grzegorz Litwinienko, Lukasz Pulaski   +6 more
wiley   +1 more source

Clinical Relevance of Plasma Endogenous Tissue-Plasminogen Activator and Aortic Valve Sclerosis: Performance as a Diagnostic Biomarker

, 2020
Zhongli Chen, Ying Shen, Qiqi Xue, Bo Wen Lin, Xiao Yan He, Yibo Zhang, Ying Yang, Wei Feng Shen, Ye Hong Liu, Ke Yang   +9 more
openalex   +1 more source

A Sacrificial 3D Printed Vessel‐on‐Chip Demonstrates a Versatile Approach to Model Granulation Tissue

Advanced Healthcare Materials, EarlyView.
A novel method that combines 3D printing and organ‐on‐chip technology enables the creation of hollow channels lined with endothelial cells through a fibroblast‐populated connective tissue matrix. The model supports stable metabolic culture conditions, angiogenic sprouting, and immune cell migration, thereby demonstrating an easy and versatile method to
Jonas Jäger, Phil Berger, Andrew I. Morrison, Hendrik Erfurth, Maria Thon, Eva‐Maria Dehne, Susan Gibbs, Jasper J. Koning   +7 more
wiley   +1 more source

AD-related plasma biomarkers in centenarians: links to cognition and neuropathology. [PDF]

Alzheimers Dement
Lorenz LMC, Rohde SK, Luimes MC, Rozemuller AJM, Bank NB, Hulsman M, Graat MJI, van der Hoorn ME, Daatselaar DAH, Gouda M, Hoozemans JJM, Sikkes SAM, Teunissen CE, Holstege H.   +13 more
europepmc   +1 more source

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

Editorial: Neurovascular health insights: a powerful tool to understand and prognose neurocognitive decline

Frontiers in Aging Neuroscience
Min Xia, Min Xia, Michael Ntim, Michael Ntim, Bin Wang   +4 more
doaj   +1 more source

Plasma biomarkers in neuropsychiatric syndromes: A narrative review. [PDF]

J Alzheimers Dis
Ismail Z, Guan DX, Babulal GM, Bateman JR, Cantillon M, Creese B, D'Antonio F, Fischer CE, Gatchel JR, Ghahremani M, Guerrero-Cantera J, Lanctôt KL, Mielke MM, Mortby ME, Feldman O, Pereira AC, Pereiro AX, Perry G, Potter WZ, Rabl M, Ravona-Springer R, Rosen AC, Rouse HJ, Sankhe K, Schindler SE, Udeh-Momoh CT, Tarawneh R, Oliveira FF, Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART), Biofluid Based Biomarkers in Neuropsychiatric Syndromes work group.   +29 more
europepmc   +1 more source

Doxorubicin‐Loaded Metal–Organic Framework for Ferroptosis‐Enhanced Chemotherapy Through Sustained Zn Release and Glutathione Peroxidase Downregulation

Advanced Healthcare Materials, EarlyView.
A robust zinc‐based metal–organic framework (ZnMOF) enables dual functions of doxorubicin delivery and sustained Zn2+ release to trigger ferroptosis‐enhnaced chemotherapy. DOX@ZnMOF effectively depletes intracellular glutathione, suppresses GPX4, and elevates reactive oxygen species, leading to efficient oxidative DNA damage and apoptosis.
Xin Ma, Chenghua Deng, Chaoyu Wang, Langston Tilman, Jinhong Li, Wenbin Lin   +5 more
wiley   +1 more source

Epigenetic clocks and longitudinal plasma biomarkers of Alzheimer's disease. [PDF]

Alzheimers Dement
Zhang B, McEvoy LK, Nguyen S, Espeland MA, Rapp SR, Horvath S, Lu AT, LaCroix AZ, Nievergelt CM, Maihofer AX, Resnick SM, Mielke MM, Beckman K, Li D, Silver B, Manson JE, Ferrucci L, Shadyab AH.   +17 more
europepmc   +1 more source