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Relevance of plasma biomarkers to imaging biomarkers
Alzheimer's & Dementia, 2023AbstractBackgroundRecent advances in blood‐based biomarkers have shown promising abilities to estimate brain pathological statuses related to amyloid‐β (Aβ) deposition, phosphorylated tau deposition, and neurodegeneration using minimally invasive methods.
Akinori Nakamura +9 more
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On the Development of Plasma Protein Biomarkers
Journal of Proteome Research, 2011The development of plasma biomarkers has proven to be more challenging than initially anticipated. Many studies have reported lists of candidate proteins rather than validated candidate markers with an assigned performance to a specific clinical objective.
Surinova Silvia +5 more
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Plasma biomarkers of Alzheimer's disease
Current Opinion in Psychiatry, 2008The importance of biomarkers of Alzheimer's disease is increasing. The present review aims to offer a general view of plasma biomarkers of Alzheimer's disease and to discuss their relevance and limitations.The broad overlap in the plasma amyloid beta protein (Abeta) levels between patients with Alzheimer's disease and control individuals indicates that
Takeshi, Kawarabayashi, Mikio, Shoji
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Genetic architecture of plasma Alzheimer’s disease biomarkers
Alzheimer's & Dementia, 2023AbstractBackgroundCase‐control genome‐wide association studies (GWAS) have identified loci associated with risk for Alzheimer disease (AD), but they require very large sample sizes and identify variants with small effect sizes. GWAS of informative endophenotypes for disease have more power to identify novel variants and provide information about ...
Joseph Bradley +21 more
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