Results 151 to 160 of about 145,148 (243)

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Primary plasmablastic plasma cell leukemia: A diagnostic conundrum. [PDF]

EJHaem
Chiriac R, Fontaine J.
europepmc   +1 more source

Advances and challenges in experimental models for Epstein–Barr virus research

mLife, EarlyView.
Abstract Epstein–Barr virus (EBV), the first identified human oncovirus, is a ubiquitous γ‐herpesvirus etiologically linked to diverse malignancies, lymphoproliferative disorders, and autoimmune diseases. Experimental models are pivotal for unraveling the infection and pathogenesis mechanisms, life cycle regulation, as well as development and ...
Gulimire Wufuer, Jiabao Tang, Tingdong Li, Shengxiang Ge, Jun Zhang, Ningshao Xia   +5 more
wiley   +1 more source

Plasma Cell Leukemia With Spindle-Cell Morphology and CD22 Positivity on Flow Cytometry. [PDF]

Cureus
Udoh AI, Wagner C, Rawas F, Mallick J, Aakash F.   +4 more
europepmc   +1 more source

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

The Journal of Pathology, EarlyView.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi, Irene Torresan, Emilio Francesco Giunta, Sara Bleve, Nicole Brighi, Elisa Tassinari, Sofia Zanuccoli, Maria Concetta Cursano, Cristian Lolli   +8 more
wiley   +1 more source

Impact of t(11;14) primary cytogenetic abnormality and the cumulative effect of multiple high-risk cytogenetics at diagnosis on the outcomes of patients with primary plasma cell leukemia. [PDF]

Blood Cancer J
Hellou T, Kumar SK, Alouch SS, Almodovar-Diaz A, Dispenzieri A, Jevremovic D, Buadi FK, Dingli D, Zanwar S, Hayman SR, Kapoor P, Leung N, Fonder A, Hobbs M, Hwa YL, Muchtar E, Warsame R, Kourelis TV, Cook J, Binder M, Abdallah N, Lin Y, Go RS, Siddiqui MA, Kyle RA, Gertz MA, Rajkumar SV, Gonsalves WI.   +27 more
europepmc   +1 more source

Semi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.
Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre, Corinna Maier, Jiuhong Zha, Benjamin Engelhardt, Johannes E. Wolff, Sven Mensing   +5 more
wiley   +1 more source

Outcomes and treatment patterns in primary and secondary plasma cell leukemia: insights from a large US cohort study. [PDF]

Haematologica
Singh S, Peshin S, Wertheim BC, Larsen A, Chineke I, Sborov DW, Green D, Liedtke M, Okoniewski M, Wazir M, Nadeem O, Schachter LG, DeGraaff D, Vardell VA, Coffey DG, Gowin K.   +15 more
europepmc   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

A Case of Plasma Cell Leukemia Arising De Novo: A Rare and Fatal Disease. [PDF]

Cureus
Sweidan HB, Jarrah A, Zhu F, Wang Y.
europepmc   +1 more source