Results 71 to 80 of about 163,414 (297)

Importance of the carboxyl terminus of FAT/CD36 for plasma membrane localization and function in long-chain fatty acid uptakes⃞

Journal of Lipid Research, 2007
This study investigates the role of the cytoplasmic C terminus of fatty acid translocase (FAT/CD36) in localization of the molecule to the plasma membrane, its insertion into lipid rafts, and its ability to enhance long-chain fatty acid uptake in ...
Nicholas S. Eyre, Leslie G. Cleland, Narendra N. Tandon, Graham Mayrhofer   +3 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Permeation mechanisms of hydrogen peroxide and water through Plasma Membrane Intrinsic Protein aquaporins

Biochemical Journal
Hydrogen peroxide (H2O2) transport by aquaporins (AQP) is a critical feature for cellular redox signaling. However, the H2O2 permeation mechanism through these channels remains poorly understood. Through functional assays, two Plasma membrane Intrinsic Protein (PIP) AQP from Medicago truncatula, MtPIP2;2 and MtPIP2;3 have been identified as pH-gated ...
Jonathan Chevriau, Gerardo Zerbetto De Palma, Cintia Jozefkowicz, Victoria Vitali, Agustina Canessa Fortuna, Nicolas Ayub, Gabriela Soto, Gerd Patrick Bienert, Ari Zeida, Karina Alleva   +9 more
openaire   +2 more sources

Overexpression of TaPIP1A enhances drought and salt stress tolerance in Arabidopsis: cross-species conservation and molecular dynamics

Frontiers in Plant Science
Understanding the mechanisms underlying plant responses to abiotic stress is crucial for improving crop resilience. This study characterizes the role of TaPIP1A, a member of the plasma membrane intrinsic proteins (PIPs) in wheat, highlighting its ...
Jie Han, Wei Zhang, Liya Zhi, Silong Chen, Hui Zhao, Xinyu Zhang, Liuge Xue, Jun Ji, Fengzhi Wang, Junming Li   +9 more
doaj   +1 more source

Lipid rafts: bringing order to chaos

Journal of Lipid Research, 2003
Lipid rafts are subdomains of the plasma membrane that contain high concentrations of cholesterol and glycosphingolipids. They exist as distinct liquid-ordered regions of the membrane that are resistant to extraction with nonionic detergents.
Linda J. Pike
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Harnessing the Membrane Translocation Properties of AB Toxins for Therapeutic Applications

Toxins, 2021
Over the last few decades, proteins and peptides have become increasingly more common as FDA-approved drugs, despite their inefficient delivery due to their inability to cross the plasma membrane.
Numa Piot, F. Gisou van der Goot, Oksana A. Sergeeva   +2 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

The Nodulin 26-like intrinsic membrane protein OsNIP3;2 is involved in arsenite uptake by rice lateral roots

, 2017
Previous studies have shown that the Nodulin 26-like intrinsic membrane protein (NIP) Lsi1 (OsNIP2;1) is involved in arsenite [As(III)] uptake in rice (Oryza sativa). However, the role of other rice NIPs in As(III) accumulation in planta remains unknown.
Moore, KL, Zhao, Fang-Jie, Miller, A. J., Yi Chen, Steve P. McGrath, Zhao, F-J., Fang-Jie Zhao, Frans J. M. Maathuis, McGrath, S, Maathuis, Franciscus Johannes Maria, Moore, Katie L.; id_orcid, Liu, Guidong, Zhong Tang, Tang, Zhong, Miller, Anthony J, Sun, S-K., McGrath, S. P., Tang, Z., Zhao, FJ, Katie L. Moore, Chen, Yi, Chen, Y., Sheng-Kai Sun, McGrath, Steve P., Moore, K. L., Maathuis, Frans J M, Tang, Z, Miller, Antony J., Sun, Sheng Kai, Maathuis, F. J. M., Sun, S, Antony J. Miller, Liu, G., Guidong Liu   +33 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source