Results 81 to 90 of about 4,009,281 (300)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Trends in Protein-Based Biosensor Assemblies for Drug Screening and Pharmaceutical Kinetic Studies

Molecules, 2014
The selection of natural and chemical compounds for potential applications in new pharmaceutical formulations constitutes a time-consuming procedure in drug screening. To overcome this issue, new devices called biosensors, have already demonstrated their
Ana M. Gonçalves, Augusto Q. Pedro, Fátima M. Santos, Luís M. Martins, Cláudio J. Maia, João A. Queiroz, Luís A. Passarinha   +6 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Identification of fibrin clot-bound plasma proteins [PDF]

, 2012
Several proteins are known to bind to a fibrin network and to change clot properties or function. In this study we aimed to get an overview of fibrin clot-bound plasma proteins. A plasma clot was formed by adding thrombin, CaCl2 and aprotinin to citrated
Frank W G Leebeek, Talens, Simone, Demmers, Jeroen, Rijken, D.C. (Dingeman), Rijken, Dick, Dingeman C Rijken, Leebeek, F.W.G. (Frank), Simone Talens, Talens, S. (Simone), Jeroen A A Demmers, Leebeek, Frank; id_orcid, Demmers, J.A.A. (Jeroen), Talens Simone, Demmers Jeroen A. A., Rijken Dingeman C., Leebeek Frank W. G.   +15 more
core   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Proteome-wide Mendelian randomization analysis of plasma proteins identifies biomarkers for anxiety disorders

Sichuan jingshen weisheng
BackgroundAnxiety disorder is a common mental disorder， with its prevalence showing a continuous upward trend， significantly affecting the quality of life and social function of patients.
Li Xuelian, Deng Min, Ran Rongting, He Yuqian, Wang Geman, Li Yujie, Zou Zhili   +6 more
doaj   +1 more source

Nocodazole, a microtubule-active drug, interferes with apical protein delivery in cultured intestinal epithelial cells (Caco-2) [PDF]

, 1989
The polarized delivery of membrane proteins to the cell surface and the initial secretion of lysosomal proteins into the culture medium were studied in the polarized human intestinal adenocarcinoma cell line Caco-2 in the presence or absence of the ...
Hauri, H.P., Klumperman, J., Eilers, U., U Eilers, J Klumperman, Hauri, H. P., H P Hauri, Klumperman J, Hauri HP, Eilers U   +9 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Microneedle-based sampling of dermal interstitial fluid biomacromolecules: transport constraints, design principles, and diagnostic translation

Frontiers in Sensors
Dermal interstitial fluid (ISF) has emerged as a viable alternative sample for minimally invasive biomacromolecules analysis, containing proteins, immunoglobulins, nucleic acids, and extracellular vesicles that reflect both systemic physiology and local ...
Sahil Malhotra, Arun H. S. Kumar
doaj   +1 more source

Seasonal effects on the hematology and blood plasma proteins of two species of mice <em>Mus musculus domesticus</em> and <em>M. spretus</em> (Rodentia: Muridae) from Portugal

Hystrix, the Italian Journal of Mammalogy, 1994
<strong>Abstract</strong> Blood samples were taken from <em>Mus musculus domesticus</em> (Rutty, 1772) and <em>M. spretus</em> (Lataste, 1883), live-trapped at one month intervals, from September 88 to July 89, in the
António Mira, Maria da Luz Mathias
doaj   +1 more source