Results 81 to 90 of about 1,632,079 (301)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Causal inference study of plasma proteins and blood metabolites mediating the effect of obesity-related indicators on osteoporosis

Frontiers in Endocrinology
BackgroundOsteoporosis and obesity are both major global public health problems. Observational studies have found that osteoporosis might be related to obesity. Mendelian randomization (MR) analysis could overcome the limitations of observational studies
Maomao Huang, Maomao Huang, Maomao Huang, Fei Xing, Fei Xing, Yue Hu, Fuhua Sun, Fuhua Sun, Chi Zhang, Chi Zhang, Chi Zhang, Zhangyu Xv, Yue Yang, Qi Deng, Ronglan Shi, Lei Li, Jiayi Zhu, Fangyuan Xu, Dan Li, Dan Li, Jianxiong Wang, Jianxiong Wang, Jianxiong Wang   +22 more
doaj   +1 more source

Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19

Cell Reports Medicine, 2020
Summary: Severe disease of SARS-CoV-2 is characterized by vigorous inflammatory responses in the lung, often with a sudden onset after 5–7 days of stable disease.
Lucie Rodriguez, Pirkka T. Pekkarinen, Tadepally Lakshmikanth, Ziyang Tan, Camila Rosat Consiglio, Christian Pou, Yang Chen, Constantin Habimana Mugabo, Ngoc Anh Nguyen, Kirsten Nowlan, Tomas Strandin, Lev Levanov, Jaromir Mikes, Jun Wang, Anu Kantele, Jussi Hepojoki, Olli Vapalahti, Santtu Heinonen, Eliisa Kekäläinen, Petter Brodin   +19 more
doaj   +1 more source

Acid Sphingomyelinase Regulates the Localization and Trafficking of Palmitoylated Proteins [PDF]

, 2019
In human, loss of Acid Sphingomeylinase (ASM/SMPD1) causes Niemann-Pick Disease, type A. ASM hydrolyzes sphingomyelins to produce ceramides but protein targets of ASM remain largely unclear. ...
Kim, Yongsoon, Lee, Chia-Fang, Li, Wenjing, Sun, Hong, Xiong, Xiahui, Yu, Jiekai, Zhang, Hul, Zhu, Linyu   +7 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Coming together to define membrane contact sites. [PDF]

, 2019
Close proximities between organelles have been described for decades. However, only recently a specific field dealing with organelle communication at membrane contact sites has gained wide acceptance, attracting scientists from multiple areas of cell ...
De Matteis, Maria Antonietta, Emr, Scott, Giordano, Francesca, Hajnóczky, György, Kornmann, Benoît, Lackner, Laura L., Levine, Tim P., Pellegrini, Luca, Reinisch, Karin, Rizzuto, Rosario, Schuldiner, Maya, Scorrano, Luca, Simmen, Thomas, Stenmark, Harald, Ungermann, Christian   +14 more
core   +7 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Seasonal effects on the hematology and blood plasma proteins of two species of mice <em>Mus musculus domesticus</em> and <em>M. spretus</em> (Rodentia: Muridae) from Portugal

Hystrix, the Italian Journal of Mammalogy, 1994
<strong>Abstract</strong> Blood samples were taken from <em>Mus musculus domesticus</em> (Rutty, 1772) and <em>M. spretus</em> (Lataste, 1883), live-trapped at one month intervals, from September 88 to July 89, in the
António Mira, Maria da Luz Mathias
doaj   +1 more source

Characterization of MRIP2 as a NO-sensitive guanylyl cyclase-associated protein [PDF]

, 2009
Poster presentation: NO-sensitive guanylyl cyclases (sGCs) are cytosolic receptors for nitric oxide (NO) catalyzing the conversion of GTP to cGMP. sGCs are obligate heterodimers composed of one alpha and beta subunit each. The allosteric mechanism of sGC
Gross, Steffen, Matt, Simone, Meurer, Sabine, Müller-Esterl, Werner   +3 more
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source