Results 111 to 120 of about 207,763 (300)

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

British Journal of Pharmacology, EarlyView.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf, Laura J. Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann, Ines Liebscher, Alessandro Nicoli, Masha Y. Niv, Lior Peri, Hannes Schihada, Gunnar Schulte   +10 more
wiley   +1 more source

Adiposity, aldosterone and plasma renin activity among African Americans: The Jackson Heart Study. [PDF]

Endocr Metab Sci, 2023
Lee G, Kluwe B, Zhao S, Kline D, Nedungadi D, Brock GN, Odei JB, Kesireddy V, Pohlman N, Sims M, Effoe VS, Wu WC, Kalyani RR, Wand GS, Echouffo-Tcheugui J, Golden SH, Joseph JJ.   +16 more
europepmc   +1 more source

Gender differences renin-angiotensin-aldosterone system and its relation to humoral factors in patients with arterial hypertension [PDF]

Системные гипертензии, 2015
Aim. Explore gender characteristics of the renin-angiotensin-aldosterone system (RAAS), to assess the state of the RAAS relationship with the level of female sex hormones, aldosterone, plasma renin activity in patients with arterial hypertension (AH) in ...
G M Dadashova
doaj  

Airway Management of Hypokalaemic Paralysis with Trismus and Bulbar Palsy Due To Conn's Syndrome

The Laryngoscope, EarlyView.
Cristian Aragón‐Benedí, Ana Pascual‐Bellosta, Sonia Ortega‐Lucea, Javier Martinez‐Ubieto   +3 more
wiley   +1 more source

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, EarlyView.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

Bi-allelic REN Mutations and Undetectable Plasma Renin Activity in a Patient With Progressive CKD. [PDF]

Kidney Int Rep, 2023
Jorge S, Kidd K, Vylet'al P, Nogueira E, Martin L, Howard K, Barešová V, Hodaňová K, Hnízda A, Moldovan O, Silveira C, Coutinho AM, Lopes JA, Bleyer AJ, Kmoch S, Živná M.   +15 more
europepmc   +1 more source

Renovascular hypertension and plasma renin activity. [PDF]

, 1979
J M McDonald, J H Ladenson, T James
openalex   +1 more source

Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Our previous study reported that fructose intake increased systemic blood pressure and reduced nitric oxide (NO) in the nucleus tractus solitarius (NTS) due to oxidative stress and neuroinflammation. However, it remains unclear how reactive oxygen species (ROS) reduce NO and how this process impacts neuroinflammation in ...
Yu‐Te Lin, Chiu‐Yi Ho, Gwo‐Ching Sun, Tzyy‐Yue Wong, Michael Hsiao, Ching‐Jiunn Tseng, Pei‐Wen Cheng   +6 more
wiley   +1 more source

The spectrum of plasma renin activity and hypertension diseases: Utility, outlook, and suggestions. [PDF]

J Clin Lab Anal, 2022
Liu Z, Jin L, Zhou W, Zhang C.
europepmc   +1 more source

Tools to Predict Unilateral Primary Aldosteronism and Optimise Patient Selection for Adrenal Vein Sampling: A Systematic Review

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Primary aldosteronism (PA), the most common endocrine cause of hypertension, is evaluated using adrenal vein sampling (AVS), to determine if aldosterone excess is bilateral or unilateral. AVS is invasive and technically challenging; it would ideally be used only in those with unilateral PA who are candidates for surgical cure.
Elisabeth Ng, Stella May Gwini, Winston Zheng, Peter J. Fuller, Jun Yang   +4 more
wiley   +1 more source