Results 141 to 150 of about 93,450 (318)

Sodium–glucose cotransporter 2 inhibitors for hypertension in cardiovascular–kidney–metabolic syndrome

Experimental Physiology, EarlyView.
Abstract The antihypertensive mechanism of sodium–glucose cotransporter 2 (SGLT2) inhibitors has been traditionally attributed to osmotic diuresis. However, emerging evidence reveals multifaceted mechanisms beyond diuresis, including regulation of the renin–angiotensin–aldosterone system, sympathetic nervous system suppression, ion homeostasis ...
Chunxiang Xu, Xingyu Qiu, Nan Xu, Gensheng Zhang, Enyin Lai, Liang Zhao   +5 more
wiley   +1 more source

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

Experimental Physiology, EarlyView.
Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó, Luis Eduardo M. Quintas   +1 more
wiley   +1 more source

Early acclimatization to high altitude: Acid–base and fluid balance dynamics during the first 2 days at 3100 m

Experimental Physiology, EarlyView.
Abstract Immediate responses to hypoxia at high altitude are hyperventilation and successive respiratory alkalosis. Alkalosis, in turn, can affect cerebrospinal fluid pH and ventilatory control. The kidneys compensate metabolically for respiratory alkalosis.
Elisabeth Skalla, Benedikt Treml, Sasa Rajsic, Michael Schreinlechner, Zoran Bukumirić, Klaus Berek, Alexander Egger, Johann Knotzer, Martin Burtscher, Axel Kleinsasser   +9 more
wiley   +1 more source

Effect of Atenolol(Tenormin®) on Blood Pressure and Plasma Renin Activity in Essential Hypertension

, 1982
Soon Kyu Suh, Sae Wha Yoo, Soon Chang Park, Joon Sock Kim, Kyung Ho Kang, Ki Suh Park   +5 more
openalex   +1 more source

The role of atrial natriuretic peptide (ANP) in chronic liver disease. [PDF]

, 1993
Almeida, Angeli, Arendt, Arendt, Badalamenti, Ballermann, Bendtsen, Bernardi, Bernardi, Beutler, Brenard, Buckalew, Cachofeiro, Cantin, Chinkers, Colantonio, De Wardener, Dussaule, Epstein, Epstein, Field, Firth, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Ginés, Ginés, Gutkowska, Heim, Henriksen, Henriksen, Henriksen, Henriksen, Inagami, Jiménez, Klepetko, Kollenda, Kollenda, Kramer, La Villa, Laffi, Lang, Lang, Larose, Lenz, López, Maack, Maher, Miyase, Morali, Moreau, Morgan, Naccarato, Nair, Needleman, Panos, Panos, Panos, Pilz, Rashed, Rector, Salerno, Salerno, Schrier, Tesar, Tesar, Trevisani, Tulassay, Uemura, Vinel, Vollmar, Warner, Wilcox, Withrington, Witthaut   +82 more
core   +1 more source

Early life stress and disruption of the ageing trajectory in female rats: Insights into the origins and mechanisms underlying the risk of hypertension

Experimental Physiology, EarlyView.
Abstract Menopause increases the risk of hypertension in women, yet the factors contributing to this important change remain unclear. Because early life stress has persistent and sex‐specific consequences on health, we hypothesized that ageing reveals the latent effects of neonatal maternal separation (NMS) on cardiovascular homeostasis in female rats.
Danuzia Ambrozio‐Marques, Loralie Mei Guay, Alicia A. Koogler, Tim D. Ostrowski, Aline M. Arlindo de Souza, Kathryn Sandberg, Richard Kinkead   +6 more
wiley   +1 more source

Higher plasma renin activity is associated with increased kidney damage risk in patients with hypertension and glucose metabolic disorders. [PDF]

J Clin Hypertens (Greenwich), 2022
Lin M, Heizhati M, Gan L, Hong J, Wu T, Xiamili Z, Tong L, Lin Y, Li N.   +8 more
europepmc   +1 more source

Idiopathic orthostatic hypotension: Recent data (eleven cases) and review of the literature [PDF]

Eight cases of Shy-Drager syndrome and three of Bradbury-Eggleston idiopathic orthostatic hypotension were examined. In all cases, examination of circulatory reflexes showed major dysfunction of the sympathetic vasoconstrictor system.
Annat, G., Boisson, D., Devic, M., Holzhapfel, L., Levrat, R., Michel, D., Ninet, J., Peyrin, L., Schott, B., Vincent, M.   +9 more
core   +1 more source

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand, Jakub Tomek, Blanca Rodriguez   +2 more
wiley   +1 more source

Arterial hypertension in hypothyrosis: severity and state of renin-aldosteron system

Российский кардиологический журнал, 2004
A survey on arterial hypertension (AH) severity and renin-angiotensin-aldosteron system activity in primary hypothyrosis was performed. Itwas demonstrated that such patients had II and III Stage of AH, with severity progression in older age, and more ...
G. B. Selivanova, P. Kh. Dzhanashiya
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