Results 81 to 90 of about 391,649 (370)

Activation of the Human Angiotensin-(1-12)-Chymase Pathway in Rats With Human Angiotensinogen Gene Transcripts

Frontiers in Cardiovascular Medicine, 2019
Angiotensin-(1-12) [Ang-(1-12)], an alternate substrate for tissue angiotensin II (Ang II) formation, underscores the importance of alternative renin-independent pathway(s) for the generation of angiotensins.
Carlos M. Ferrario, Carlos M. Ferrario, Carlos M. Ferrario, Jessica VonCannon, Sarfaraz Ahmad, Kendra N. Wright, Drew J. Roberts, Hao Wang, Tomohisa Yamashita, Leanne Groban, Che Ping Cheng, James F. Collawn, Louis J. Dell'Italia, Jasmina Varagic, Jasmina Varagic   +14 more
doaj   +1 more source

Differential renal effects of candesartan at high-and ultra-high doses in diabetic mice: potential role of  ACE2/AT2R/Mas [PDF]

, 2016
High doses of Ang II receptor (AT1R) blockers (ARBs) are renoprotective in diabetes. Underlying mechanisms remain unclear. We evaluated whether high/ultra-high doses of candesartan (ARB) up-regulate angiotensin-converting enzyme 2 (ACE2)/Ang II type 2 ...
Antunes, Tayze, Briones, Ana M., Burns, Kevin, Callera, Glaucia, Correa, Jose, Gutsol, Alexey, He, Ying, Montezano, Augusto C., Moorman, Danielle, Nguyen Dinh Cat, Aurelie, Touyz, Rhian M.   +10 more
core   +1 more source

Role for inflammatory markers in predicting right ventricular failure in mechanical assist device recipients

ESC Heart Failure, EarlyView.
Abstract Right ventricular failure (RVF) is a common complication following left ventricular assist device (LVAD) implantation and increases patient morbidity and mortality. Due to the complex and limited understanding of RVF pathophysiology, efforts to prognosticate RVF after LVAD have been challenging.
Abdul‐Fatawu Osman, Shane S. Scott, Ebubechukwu O. Ezeh, Evans Osuji, Israel O. Ailemen, Mohamed H. Derbala, Salil Kumar, Asvin M. Ganapathi, Daniel B. Sims, Ashrith Guha, Bryan A. Whitson, Sakima A. Smith   +11 more
wiley   +1 more source

Establishing a novel assay system for measuring renin concentration using cost effective recombinant ovine angiotensinogen

Heliyon, 2019
Background: Plasma renin can predict future cardiovascular events as well as the prevalence of chronic renal disease in hypertensive subjects. Ovine angiotensinogen (oANG) is a better substrate for measuring renin concentration through activity assay ...
Jobaida Akther, A.H.M. Nurun Nabi, Satoshi Ohno, Takashi Yokogawa, Tsutomu Nakagawa, Fumiaki Suzuki, Akio Ebihara   +6 more
doaj  

Lower NT‐proBNP plasma concentrations in Pacific peoples with heart failure

ESC Heart Failure, EarlyView.
NT‐proBNP plasma concentrations were measured in participants of two NZ HF cohorts and were significantly lower in Pacific peoples and Māori compared with NZ Europeans. After accounting for age, sex, BMI, eGFR, LVEF and presence of AF, NT‐proBNP plasma concentrations remained significantly lower for Pacific peoples, but not for Māori.
Andree G. Pearson, John F. Pearson, Lynley K. Lewis, Allamanda Fa'atoese, Katrina K. Poppe, Chris Pemberton, Gerry Devlin, Mayanna Lund, A. Mark Richards, Richard Troughton, Robert N. Doughty   +10 more
wiley   +1 more source

Bi-directional actions of estrogen on the renin-angiotensin system

Brazilian Journal of Medical and Biological Research, 1999
Estrogen stimulates the renin-angiotensin system by augmenting both tissue and circulating levels of angiotensinogen and renin. We show, however, that angiotensin converting enzyme (ACE) activity in the circulation and in tissues is reduced in two animal
K.B. Brosnihan, P.S. Senanayake, P. Li, C.M. Ferrario   +3 more
doaj   +1 more source

Comparative neurohormonal responses in patients with preserved and impaired left ventricular ejection fraction: Results of the studies of left ventricular dysfunctions (SOLVD) registry [PDF]

, 1993
Objectives. The aim of this study was to determine the differences in neurohumoral responses between patients with pulmonary congestion with and without impaired left ventricular ejection fraction.Background.
Benedict, Claude R., Bourassa, Martial G., Ghali, Jalal K., Greenberg, Barry, Johnstone, David E., Kirlin, Philip, Nicklas, John, Quinones, Miguel A., Weiner, Debra H., Yusuf, Salim   +9 more
core   +2 more sources

Association between NT‐proBNP changes and clinical outcomes in paediatric patients with heart failure: Insights from PANORAMA‐HF and PARADIGM‐HF

ESC Heart Failure, EarlyView.
This post hoc analysis of the PANORAMA‐HF paediatric heart failure trial evaluates the correlation of baseline and clinical changes in NT‐proBNP and clinical outcomes in children with heart failure due to left ventricular systolic dysfunction. This is the first prospective, randomized large‐scale study to demonstrate that changes in NT‐proBNP levels ...
Robert Shaddy, Jianjian Gong, Tania Garito, Susan Solar‐Yohay, Sijia Zhang, Margaret F. Prescott, Damien Bonnet, Paul F. Kantor, Michael Burch, Chad Mao, Antoinette Cilliers, Charles Canter, Yuk Law, Giorgia Grutter, Jou Kou Wang, Aamir Jeewa, Joseph Rossano, on behalf of PANORAMA‐HF investigators   +17 more
wiley   +1 more source

Plasma Renin Activity in Hypertensive Diseases [PDF]

, 1970
1970-07Plasma renin activity was determined in normotensive and hypertensive human subjects by a modification of the method of Boucher and co-workers. Simultaneous determination of plasma volume, serum electrolyte concentration and plasma renin activity ...
49521, ITASAKA, YASUNOBU
core  

Proteins associated with rehospitalization, mortality and diuretic resistance in acutely decompensated heart failure

ESC Heart Failure, EarlyView.
Abstract Aims Most proteomic analyses in patients with heart failure (HF) focus on the stable ambulatory setting; pathways that drive acute decompensated heart failure (ADHF) are largely uncharacterized. We aimed to examine the associations of cardiometabolic proteins with HF rehospitalization, mortality and diuretic response in patients with ADHF ...
Kenneth T. Hubbell, Veena S. Rao, Rebecca Scherzer, Michael G. Shlipak, Juan B. Ivery‐Miranda, Nisha Bansal, Zachary L. Cox, Jeffrey M. Testani, Michelle M. Estrella   +8 more
wiley   +1 more source