Results 111 to 120 of about 143,775 (300)

Discolouration of plasma in therapeutic plasma exchange

Indian Journal of Nephrology, 2021
Bala Kumar, SS Deepak, Fernando, Edwin M., Srinivasaprasad, ND, Valavan, K Thirumal, Sujit, S   +4 more
openaire   +2 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Mapping of the Ganymede surface reflectance from Juno/UVS data

Astronomy & Astrophysics
Context. Ganymede is the only moon in the Solar System with an intrinsic magnetic field that actively interacts with the Jupiter magnetosphere. This precipitates energetic electrons that generate ultraviolet (UV) auroral emission. Aims. In sunlit auroral
Benmahi B., Hue V., Molyneux P., Vorburger A., Waite J. H., Gronoff G., Bouquet A., Gladstone G. R., Leblanc F., Benne B., Bonfond B., Barthelemy M., Blanc M., Grodent D. C., Greathouse T. K.   +14 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

The vertical profile of the northern Io footprint auroral emission in the far-ultraviolet from Juno

Astronomy & Astrophysics
Context. The interaction between Io and the Jovian magnetosphere produces the auroral “Io footprint”, which can be observed in the ultraviolet thanks to the deexcitation of atmospheric H and H2 under electron precipitation.
Moirano A., Bonfond B., Sicorello G., Vinesse J., Szalay J., Hue V., Benmahi B., Grodent D., Head L. A., Gérard J.-C., Greathouse T. K., Gladstone G. R., Giles R. S., Versteeg M. H.   +13 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Observations of counter-streaming ions in and around the diamagnetic cavity of comet 67P

Astronomy & Astrophysics
Context. Ion speeds at comet 67P/Churyumov-Gerasimenko significantly exceed local neutral gas speeds, a discrepancy that challenges current ion-neutral coupling models.
Yun X.-T., Stenberg Wieser G., Nilsson H., Bergman S., Fu S., Ni B.   +5 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Periodicities in radio emissions from Jupiter’s magnetosphere and consequences for radio emissions from star–exoplanet systems

Astronomy & Astrophysics
Context. The search for radio signals from exoplanets or star-planet interactions is a topic of major scientific interest, as it is likely the best way to detect and measure a planetary magnetic field and, therefore, to probe the inner structure of ...
Louis C. K., Loh A., Zarka P., Lamy L., Mauduit E., Girard J., Grießmeier J.-M., Cecconi B., Nénon Q., Corbel S.   +9 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source