Results 101 to 110 of about 103,129 (319)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

On Ponderomotive Effects Induced by Alfvén Waves in Inhomogeneous 2.5D MHD Plasmas

, 2013
Where spatial gradients in the amplitude of an Alfvén wave are non-zero, a nonlinear magnetic-pressure gradient acts upon the medium (commonly referred to as the ponderomotive force).
McLaughlin, James, Thurgood, Jonathan
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Multi-wavelength emission in resistive pulsar magnetospheres

Astronomy & Astrophysics
Context. Neutron star magnetospheres are well described in the two extreme cases of a vacuum field and a plasma-filled force-free regime. However, neither of these descriptions allows for magnetic field dissipation into particle kinetic energy and thus ...
Pétri J.
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Complex plasmas: Interaction potentials and non-Hamiltonian dynamics [PDF]

, 2007
This thesis is a cumulative dissertation that consists of three papers. The first paper addresses the issue of screening of a charged dust particle suspended in the plasma-wall transition layer of a plasma discharge.
Kompaneets, Roman, Kompaneets, R.
core  

Distinctive plume formation in atmospheric pressure Ar and He plasmas in microwave frequency band and suitability for biomedical applications

, 2018
Distinctive discharge formation in atmospheric Ar and He plasmas was observed in the microwave frequency band using coaxial transmission line resonators. Ar plasmas formed a plasma plume whereas He formed only confined plasmas. As the frequency increased
Kim, HY, Kwon, HC, LEE, JAE KOO, Kang, SK, Won, IH, H. Wk. Lee, Sim, JY   +6 more
core   +1 more source

Temperature anisotropy, instabilities, and thermal processes in low-β plasma

Astronomy & Astrophysics
Interplanetary coronal mass ejections (ICMEs) are large-scale magnetic structures that influence heliospheric dynamics and space weather. While wave activity has been observed within their low-β (≪1) magnetic obstacles, the role of temperature anisotropy
Shaikh Zubair I., Verscharen Daniel, Vasko Ivan Y., Maruca Bennett A.   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source