Results 11 to 20 of about 1,085,040 (311)
Selection of a Multidrug Resistance Plasmid by Sublethal Levels of Antibiotics and Heavy Metals
mBio, 2014 How sublethal levels of antibiotics and heavy metals select for clinically important multidrug resistance plasmids is largely unknown. Carriage of plasmids generally confers substantial fitness costs, implying that for the plasmid-carrying bacteria to be
Erik Gullberg +4 more
openalex +2 more sources
ApE, A Plasmid Editor: A Freely Available DNA Manipulation and Visualization Program
Frontiers in Bioinformatics, 2022 A plasmid Editor (ApE) is a free, multi-platform application for visualizing, designing, and presenting biologically relevant DNA sequences. ApE provides a flexible framework for annotating a sequence manually or using a user-defined library of features.
M. Davis +4 more
semanticscholar +1 more source
Variability of plasmid fitness effects contributes to plasmid persistence in bacterial communities
Nature Communications, 2021 Plasmid persistence in bacterial populations is strongly influenced by the fitness effects associated with plasmid carriage. However, plasmid fitness effects in wild-type bacterial hosts remain largely unexplored. In this study, we determined the fitness
Aida Alonso-del Valle +8 more
semanticscholar +1 more source
Nucleic Acids Research, 2021 Plasmids and temperate phages are key contributors to bacterial evolution. They are usually regarded as very distinct. However, some elements, termed phage–plasmids, are known to be both plasmids and phages, e.g. P1, N15 or SSU5. The number, distribution,
E. Pfeifer +3 more
semanticscholar +1 more source
DNA Minicircle Technology Improves Purity of Adeno-associated Viral Vector Preparations
Molecular Therapy: Nucleic Acids, 2016 Adeno-associated viral (AAV) vectors are considered as one of the most promising delivery systems in human gene therapy. In addition, AAV vectors are frequently applied tools in preclinical and basic research. Despite this success, manufacturing pure AAV
Maria Schnödt +9 more
doaj +1 more source
Pathogens, 2021 Klebsiella pneumoniae carbapenemase (KPC) actively hydrolyzes carbapenems, antibiotics often used a last-line treatment for multidrug-resistant bacteria. KPC clinical relevance resides in its widespread dissemination.
Letícia B. Migliorini +10 more
doaj +1 more source
Microorganisms, 2021 Fluoroquinolones are the highest priority, critically important antimicrobial agents. Resistance development can occur via different mechanisms, with plasmid-mediated quinolone resistance (PMQR) being prevalent in the livestock and food area. Especially,
Katharina Juraschek +8 more
doaj +1 more source
Vaccines, 2020 Influenza viruses infect millions of people each year, resulting in significant morbidity and mortality in the human population. Therefore, generation of a universal influenza virus vaccine is an urgent need and would greatly benefit public health ...
Jeffrey W. Ecker +8 more
doaj +1 more source
Antibiotics, 2021 Background: The emergence of plasmid-mediated antibiotic resistance in Escherichia coli in water resources could pose a serious threat to public health. The study aims to investigate the dispersion of plasmid-mediated antibiotic-resistant E.
Samuel Lihan +3 more
doaj +1 more source
Microbial Genomics, 2020 Bacterial plasmids play a large role in allowing bacteria to adapt to changing environments and can pose a significant risk to human health if they confer virulence and antimicrobial resistance (AMR).
James Robertson +3 more
semanticscholar +1 more source