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Fitness Costs of Plasmids: a Limit to Plasmid Transmission [PDF]
Microbiology Spectrum, 2017 ABSTRACT Plasmids mediate the horizontal transmission of genetic information between bacteria, facilitating their adaptation to multiple environmental conditions. An especially important example of the ability of plasmids to catalyze bacterial adaptation and evolution is their instrumental role in the global spread of antibiotic resistance ...
San Millan, A, Maclean, R
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Plasmid persistence: costs, benefits, and the plasmid paradox [PDF]
Canadian Journal of Microbiology, 2018 Plasmids are extrachromosomal DNA elements that can be found throughout bacteria, as well as in other domains of life. Nonetheless, the evolutionary processes underlying the persistence of plasmids are incompletely understood. Bacterial plasmids may encode genes for traits that are sometimes beneficial to their hosts, such as antimicrobial resistance,
Carroll, Amanda C., Wong, Alex
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Plasmid, 2023 Plasmids are universally present in bacteria and play key roles in the dissemination of genes such as antibiotic resistance determinants. Major concepts in Plasmid Biology derive from the efforts to classify plasmids. Here, we review the main plasmid classification systems, starting by phenotype-based methods, such as fertility inhibition and ...
Garcillán-Barcia, M. Pilar +2 more
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Microbiology and Molecular Biology Reviews, 2010 SUMMARYPlasmids are key vectors of horizontal gene transfer and essential genetic engineering tools. They code for genes involved in many aspects of microbial biology, including detoxication, virulence, ecological interactions, and antibiotic resistance.
Smillie, C. +4 more
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Variability of plasmid fitness effects contributes to plasmid persistence in bacterial communities
Nature Communications, 2021 Plasmid persistence in bacterial populations is strongly influenced by the fitness effects associated with plasmid carriage. However, plasmid fitness effects in wild-type bacterial hosts remain largely unexplored. In this study, we determined the fitness
Aida Alonso-del Valle +8 more
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Nucleic Acids Research, 2021 Plasmids and temperate phages are key contributors to bacterial evolution. They are usually regarded as very distinct. However, some elements, termed phage–plasmids, are known to be both plasmids and phages, e.g. P1, N15 or SSU5. The number, distribution,
E. Pfeifer +3 more
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Plasmid-to-plasmid recombination in Haemophilus influenzae [PDF]
Journal of Bacteriology, 1986 No recombination between plasmids was observed after conjugal transfer of a plasmid into a cell carrying another plasmid. Two types of such recombination took place after transformation, one type being Rec+ dependent and suggesting a preferred site of recombination. The other much rarer type was at least partially Rec+ independent.
Jane K. Setlow, Meenakshi Balganesh
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Frontiers in Cellular and Infection Microbiology, 2023 Salmonella is one of the most important zoonotic pathogens and a major cause of foodborne illnesses, posing a serious global public health hazard. The emergence of plasmid-mediated mcr genes in Salmonella has greatly reduced the clinical choice of ...
Xinran Sun +12 more
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DNA Minicircle Technology Improves Purity of Adeno-associated Viral Vector Preparations
Molecular Therapy: Nucleic Acids, 2016 Adeno-associated viral (AAV) vectors are considered as one of the most promising delivery systems in human gene therapy. In addition, AAV vectors are frequently applied tools in preclinical and basic research. Despite this success, manufacturing pure AAV
Maria Schnödt +9 more
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Remarkable stability of an instability-prone lentiviral vector plasmid in Escherichia coli Stbl3 [PDF]
, 2012 Large-scale production of plasmid DNA to prepare therapeutic gene vectors or DNA-based vaccines requires a suitable bacterial host, which can stably maintain the plasmid DNA during industrial cultivation.
Al-Allaf, FA +4 more
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