Results 231 to 240 of about 2,233,350 (305)

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

Plasmid DNA Delivery into the Skin via Electroporation with a Depot-Type Electrode. [PDF]

Pharmaceutics
Yoshida Y, Aoki M, Nagase K, Marubashi K, Kojima H, Itakura S, Komatsu S, Sugibayashi K, Todo H.   +8 more
europepmc   +1 more source

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

Desiccated Cyanobacteria Serve As Efficient Plasmid DNA Carriers in Space Flight. [PDF]

ACS Synth Biol
Kakouridis A, Diamond S, Eng T, Mills HJ, Gámez Holzhaus O, Summers ML, Garcia-Pichel F, Mukhopadhyay A.   +7 more
europepmc   +1 more source

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

Plasmid DNA Complexes in Powder Form Studied by Spectroscopic and Diffraction Methods. [PDF]

Materials (Basel)
Radko A, Lalik S, Górska N, Deptuch A, Świergiel J, Marzec M.   +5 more
europepmc   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

From plasmid sequence to process design: A computational analysis of metabolism in the context of plasmid DNA manufacturing

Stratis N, Morbidelli M, Kiparissides A.
europepmc   +1 more source

Plasmid DNA Delivery to Cancer Cells with Poly(L-lysine)-Based Copolymers Bearing Thermally Sensitive Segments: Balancing Polyplex Tightness, Transfection Efficiency, and Biocompatibility. [PDF]

Pharmaceutics
Kotmakci M, Toncheva-Moncheva N, Tarkavannezhad S, Debelec Butuner B, Dimitrov I, Rangelov S.   +5 more
europepmc   +1 more source

Extracellular vesicle mimetics as delivery vehicles for oligonucleotide-based therapeutics and plasmid DNA. [PDF]

Front Bioeng Biotechnol
Oshchepkova A, Chernikov I, Miroshnichenko S, Patutina O, Markov O, Savin I, Staroseletz Y, Meschaninova M, Puchkov P, Zhukov S, Kupryushkin M, Maslov M, Sen'kova A, Vlassov V, Chernolovskaya E, Zenkova M.   +15 more
europepmc   +1 more source