Results 241 to 250 of about 741,058 (313)

EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier

The FEBS Journal, EarlyView.
Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto, Gergő Porkoláb, Natalie Hudson, Jeffrey O'Callaghan, Nicole Hanley, Conor Delaney, Mária A. Deli, Peter Westenskow, Matthew Campbell   +8 more
wiley   +1 more source

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

The FEBS Journal, EarlyView.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna, Christoff Odendaal, Madhulika Singh, Albert Gerding, Miriam Langelaar‐Makkinje, Marianne van der Zwaag, Asmara Drachman, Vladimíra Cetkovská, Gaby Liem Foeng Kioen, Anne‐Claire M. F. Martines, Nicolette C. A. Huijkman, Hein Schepers, Bart van de Sluis, Dirk‐Jan Reijngoud, Ody C. M. Sibon, Amy C. Harms, Thomas Hankemeier, Barbara M. Bakker   +17 more
wiley   +1 more source

Co-condensation between transcription factor and cBAF selectively modulates chromatin remodeling and gene expression. [PDF]

Nat Commun
Ye X, Xu L, Sun X, Gai Y, Yang H, Sun Q, Song J, Huang P, Zhou Q, Li Y, Li N, Jin J, Li Y, Rao W, Lu H, Wang P, Chang C, Lu Y.   +17 more
europepmc   +1 more source

Latent Neoehrlichia mikurensis Infections May Be Reactivated in Patients With B‐Cell Lymphomas Treated With Rituximab

Immunology, EarlyView.
Eight percent of this cohort of patients had a latent Neoehrlichia mikurensis infection. It was only the latently infected patients who had N. mikurensis‐specific T cells, not the matched B‐cell lymphoma patients without the infection. The T‐cell responses of latently infected patients included perforin‐expressing Th1 and CD8+ T cells that upregulated ...
Linda Wass, Catharina Lewerin, Daniel Jaén‐Luchoro, Christine Lingblom, Christine Wennerås   +4 more
wiley   +1 more source

Dissociation of the nuclear basket triggers chromosome loss in aging yeast. [PDF]

Elife
Mirkovic M, McCarthy J, Meinema AC, Parenteau J, Lee SS, Elela SA, Barral Y.   +6 more
europepmc   +1 more source

Proteomic analysis of the zone of degeneration at the mitosis–meiosis transition stage in wild‐caught male catshark (Scyliorhinus canicula), correlated with an unusually high‐water temperature in the English Channel

Journal of Fish Biology, EarlyView.
Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne, Stanislas Pilet, Sean Heighton, Benoît Bernay, Pascal Sourdaine   +4 more
wiley   +1 more source

Distinct liquid-liquid phase separation properties of end-binding proteins EB1 and EB3. [PDF]

J Biol Chem
Boyko S, Li Q, Surewicz K, Surewicz WK.
europepmc   +1 more source

GeARF5/GeIAA33‐GeSWEET14 module balances the secondary metabolic biosynthesis to increase the yield and quality in Gastrodia elata

Journal of Integrative Plant Biology, EarlyView.
Auxin signaling regulates the formation of vegetative propagation corms in Gastrodia elata by regulating sugar‐acid interconversion, which in turn regulates polysaccharide and starch biosynthesis as well as biosynthesis of the bioactive metabolite gastrodin.
Qun Liu, Zhiqing Wu, Yugang Gao, Yue Xu, Pu Zang, Xinyu Yang, Yan Zhao, Pan Liao, Benoît Boachon, Guoyin Kai   +9 more
wiley   +1 more source

POMPOMS: Crosslinked Biomolecular Condensates as a Versatile Platform for Multifunctional Protein Microparticles. [PDF]

Biomacromolecules
Park AS, Ding EA, Schuster BS.
europepmc   +1 more source

A natural variation within duplicated AsWRKY49‐D2 drives the subgenomic functional divergence of homeologs in salt response of allohexaploid oats

Journal of Integrative Plant Biology, EarlyView.
Transcriptome analysis of oats under salt stress identified ten important salt‐responsive transcription factor families, which show extensive functional divergence among three oat subgenomes. Further integration with a genome‐wide association study under salt stress identified the AsWRKY49‐D2 gene, whose elite haplotype holds substantial potential for ...
Cailian Du, Yange Yun, Wenjia Li, Xiaolu Wu, Xingyu Liu, Minghao Li, Yingying Li, Shuhui Wang, Wei Li, Qiang He, Zhizhong Gong, Huilong Du, Qingbin Sun   +12 more
wiley   +1 more source