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Unraveling enhanced liver regeneration in ALPPS: Integrating multi-omics profiling and in vivo CRISPR in mouse models. [PDF]

Hepatol Commun
Du Y, Yang Y, Zhang Y, Zhang F, Wu J, Yin J.   +5 more
europepmc   +1 more source

Plasmid Localization and Partition in Enterobacteriaceae

EcoSal Plus, 2019
Plasmids are ubiquitous in the microbial world and have been identified in almost all species of bacteria that have been examined. Their localization inside the bacterial cell has been examined for about two decades; typically, they are not randomly distributed, and their positioning depends on copy number and their mode of segregation ...
Jean-Yves, Bouet, Barbara E, Funnell
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P1 Plasmid Partition: A Mutational Analysis of ParB

Journal of Molecular Biology, 1996
P1 plasmid partition to daughter cells requires plasmid proteins, ParA and ParB, and a centromere analog, parS, to which ParB binds. ParA and ParB decrease the loss frequencies of some low copy number plasmid vectors with parS inserts, as well as that of P1 itself, more than 100-fold.
M, Lobocka, M, Yarmolinsky
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Topological Scanning of the P1 Plasmid Partition Site

Journal of Molecular Biology, 1994
The parS site of the P1 plasmid promotes active partition of P1 to daughter cells when the P1 ParA and ParB proteins are provided. The structure of parS was modified by substituting portions of the sequence with synthetic oligonucleotides and testing partition activity of the resulting mutants in an in vivo assay.
Hayes, Finbarr, Austin, Stuart
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Chromosome and Plasmid Partition in Escherichia coli

Annual Review of Biochemistry, 1992
INTRODUCTION 283 ANALYSIS OF GENES INVOLVED IN CHROMOSOME PARTITION 286 Two Categories of Mechanisms.. . . . . . . . .. . . . . . ....... . . . . ... . . . . . . . . . . . . . ..... . . . . . . 286 Bacterial par Mutants Defective in Topoisomerases .... 286 muk Mutants; Mutants that Produce Chromosome-less Cells......... ........
S. Hiraga
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Plasmid partitioning systems of conjugative plasmids from Clostridium perfringens

Plasmid, 2015
Many pathogenic strains of Clostridium perfringens carry several highly similar toxin or antibiotic resistance plasmids that have 35 to 40 kb of very closely related syntenous sequences, including regions that carry the genes encoding conjugative transfer, plasmid replication and plasmid maintenance functions.
Vicki Adams, Thomas D. Watts, Dieter M. Bulach, Dena Lyras, Julian I. Rood   +4 more
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Partition-mediated incompatibility of bacterial plasmids

Cell, 1990
Stuart Austin* and Kurt Nordsttimt * Laboratory of Chromosome Biology BRI-Basic Research Program NCI-Frederick Cancer Research Facility Frederick, Maryland 21701 f Department of Microbiology Biomedical Center University of Uppsala Uppsala Sweden Two plasmid species that are unable to coexist stably in a growing population of bacteria are termed ...
S, Austin, K, Nordström
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Partitioning of the F plasmid: Overproduction of an essential protein for partition inhibits plasmid maintenance

Molecular and General Genetics MGG, 1987
Multicopy plasmids carrying the sopB gene of the F plasmid inhibit stable inheritance of a coexisting mini-F plasmid. This incompatibility, termed IncG, is found to be caused by excess amounts of the SopB protein, which is essential for accurate partitioning of plasmid DNA molecules into daughter cells.
N, Kusukawa, H, Mori, A, Kondo, S, Hiraga   +3 more
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Plasmid partitioning and the spreading of P1 partition protein ParB

Molecular Microbiology, 2004
SummaryBacterial plasmids of low copy number, P1 prophage among them, are actively partitioned to nascent daughter cells. The process is typically mediated by a pair of plasmid‐encoded proteins and a cis‐acting DNA site or cluster of sites, referred to as the plasmid centromere.
Oleg, Rodionov, Michael, Yarmolinsky
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Partition-mediated plasmid pairing

Plasmid, 2005
Plasmid partition systems are essential for the stability and thus the survival of low-copy-number plasmids in growing bacterial populations. The partition reaction is responsible for proper intracellular distribution of plasmids in the bacterial cell cycle.
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