DNA Gyrase as a Target for Quinolones
Biomedicines, 2023 Bacterial DNA gyrase is a type II topoisomerase that can introduce negative supercoils to DNA substrates and is a clinically-relevant target for the development of new antibacterials. DNA gyrase is one of the primary targets of quinolones, broad-spectrum
Angela C. Spencer, Siva S. Panda
doaj +1 more source
Quinolones modulate ghrelin receptor signaling: potential for a novel small molecule scaffold in the treatment of cachexia [PDF]
, 2018 Cachexia is a metabolic wasting disorder characterized by progressive weight loss, muscle atrophy, fatigue, weakness, and appetite loss. Cachexia is associated with almost all major chronic illnesses including cancer, heart failure, obstructive ...
Cano, Rafael +8 more
core +3 more sources
Plasmid-mediated quinolone resistance among extended spectrum beta lactase producing Enterobacteriaceae from bloodstream infections [PDF]
, 2016 The purpose of this study was to determine prevalence and molecular characterization of plasmid-mediated quinolone resistance (PMQR) genes [qnrA, qnrB, qnrC, qnrD, qnrS, aac(6′)-Ib-cr, qepA, and oqxAB] among extended-spectrum beta-lactamase (ESBL ...
Domokos, Judit +2 more
core +1 more source
Infection and Drug Resistance, 2019 Background: Quinolones are among the most effective antibiotics against Pseudomonas spp. Several chromosomal and/or plasmid-mediated quinolone-resistance mechanisms have been found in Pseudomonas.
Mohamed F El-Badawy +3 more
semanticscholar +1 more source
Genetic Background and Expression of the New qepA4 Gene Variant Recovered in Clinical TEM-1- and CMY-2-Producing Escherichia coli [PDF]
, 2017 A new QepA4 variant was detected in an O86:H28 ST156-fimH38 Escherichia coli, showing a multidrug-resistance phenotype. PAβN inhibition ofqepA4-harboring transconjugant resulted in increase of nalidixic acid accumulation.
Daniel A. Sampaio +9 more
core +6 more sources
Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones [PDF]
, 2016 Our previous paper (Wilkinson et al, 2016) used high-resolution cryo-electron microscopy to solve the structure of the Escherichia coli RecBCD complex, which acts in both the repair of double-stranded DNA breaks and the degradation of bacteriophage DNA ...
Aedo +44 more
core +5 more sources
Mutations that Separate the Functions of the Proofreading Subunit of the Escherichia coli Replicase
, 2015 The dnaQ gene of Escherichia coli encodes the Ɛ subunit of DNA polymerase III, which provides the 3\u27 - 5\u27 exonuclease proofreading activity of the replicative polymerase.
Kreuzer, Kenneth N., Whatley, Zakiya
core +1 more source
Resistance to carbapenems in non-typhoidal Salmonella enterica serovars from humans, animals and food [PDF]
, 2018 Non-typhoidal serovars of Salmonella enterica (NTS) are a leading cause of food-borne disease in animals and humans worldwide. Like other zoonotic bacteria, NTS have the potential to act as reservoirs and vehicles for the transmission of antimicrobial ...
Fernández, J. +2 more
core +3 more sources
BMC MicrobiologyBackground The emergence of fluoroquinolone resistance in clinical isolates of Klebsiella pneumoniae is a growing concern. To investigate the mechanisms behind this resistance, we studied a total of 215 K.
Sepideh Rezaei +3 more
semanticscholar +1 more source
Investigation of the Frequency of Plasmid-Dependent Quinolone Resistance Genes in Klebsiella Pneumoniae, Pseudomonas Aeruginosa and Escherichia Coli Isolated from Surgical Site Infections [PDF]
Armaghane Danesh Bimonthly Journal, 2022 Background & aim: In recent years, the rate of antibiotic resistance has been increasing which has led to the limitation of ways to control hospital infections (especially surgical site infections) and accurate treatment options.
M Gholam nezhad +5 more
doaj +1 more source