Results 61 to 70 of about 316,175 (228)

Genome‐wide screen reveals a universal role of ATP in ciprofloxacin tolerance among genetically distinct Escherichia coli persisters

mLife, EarlyView.
Abstract Bacterial persisters show tolerance to bactericidal antibiotics and play essential roles in chronic infections; however, the general mechanisms underlying persister formation and antibiotic tolerance remain insufficiently characterized. In this study, the Escherichia coli Keio library was used to identify genes involved in ciprofloxacin ...
Zhenfang Mei, Yawen Cai, Jianfeng Huang, Kedong Zhao, Zuqin Zhang, Dandan Yu, Shiyan Lu, Zeying Lai, Thomas K. Wood, Xinmiao Fu   +9 more
wiley   +1 more source

The plasmid‐borne quinolone resistance protein QnrB, a novel DnaA‐binding protein, increases the bacterial mutation rate by triggering DNA replication stress

Molecular Microbiology, 2019
Bacterial antibiotic resistance, a global health threat, is caused by plasmid transfer or genetic mutations. Quinolones are important antibiotics, partially because they are fully synthetic and resistance genes are unlikely to exist in nature ...
Xiaojing Li, Yu-jiao Zhang, Xintong Zhou, Xinling Hu, Yixuan Zhou, Di Liu, A. Maxwell, K. Mi   +7 more
semanticscholar   +1 more source

Detection of quinolone antibiotic resistance genes in Escherichia coli isolated from dairy cattle feces

Current Biomedicine
Background Livestock raised in densely populated areas can serve as reservoirs for bacteria such as Escherichia coli, which may harbor antibiotic resistance genes that threaten both animal and human health.
Muhammad Ammar Raihan, Sara Elsharkawy, Agustin Indrawati, Hadri Latif   +3 more
doaj   +1 more source

Quinolone resistance: much more than predicted

Frontiers in Microbiology, 2011
Since quinolones are synthetic antibiotics, it was predicted that mutations in target genes would be the only mechanism through which resistance could be acquired, because there will not be quinolone resistance genes in nature.
Alvaro eHernandez, Maria Blanca Sanchez, Jose L Martinez   +2 more
doaj   +1 more source

Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis. [PDF]

, 2017
Epoxides are highly useful synthons and biosynthons for the construction of complex natural products during total synthesis and biosynthesis, respectively.
Garcia-Borràs, Marc, Hirayama, Yuichiro, Houk, KN, Li, Dehai H, Li, Li, Tang, Mancheng C, Tang, Yi, Watanabe, Kenji, Zou, Yi   +8 more
core  

The Mycobacterium tuberculosis Rv0132c Gene Product Mtb‐FGD2 Can Act as an F420‐Dependent Glucose Dehydrogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi, Matthew Snee, Richard B. Tunnicliffe, Linus O. Johanissen, Matthew J. Cliff, Colin W. Levy, Derren J. Heyes, Marina Golovanova, Thomas A. Jowitt, Sam Hay, Andrew W. Munro, Jonathan P. Waltho, David Leys   +12 more
wiley   +1 more source

Research Note: Longitudinal monitoring of chicken houses in a commercial layer farm for antimicrobial resistance in Escherichia coli with special reference to plasmid-mediated quinolone resistance

Poultry Science, 2019
Plasmid-mediated quinolone resistance (PMQR) genes located on conjugative plasmids can be transferred to other bacteria in the absence of antimicrobial selective pressure.
S. Koyama, T. Murase, H. Ozaki
semanticscholar   +1 more source

Characterization of Integrons and Quinolone Resistance in Clinical Escherichia coli Isolates in Mansoura City, Egypt

International Journal of Microbiology, 2021
Escherichia coli is a common pathogen in both humans and animals. Quinolones are used to treat infections caused by Gram-negative bacteria, but resistance genes emerged.
Shaymaa H. Abdel-Rhman, Rehab M. Elbargisy, Dina E. Rizk   +2 more
doaj   +1 more source

Developing Qualitative Plasmid DNA Reference Materials to Detect Mechanisms of Quinolone and Fluoroquinolone Resistance in Foodborne Pathogens

Foods, 2022
The aim of this study was to develop homogeneous and stable plasmid DNA reference materials for detecting the mechanisms of resistance to quinolones and fluoroquinolones in foodborne pathogens.
Qinya Niu, Xiumin Su, Luxin Lian, Jinling Huang, Shutong Xue, Wei Zhou, Hongyang Zhao, Xing’an Lu, Shenghui Cui, Jia Chen, Baowei Yang   +10 more
doaj   +1 more source

Complete nucleotide sequence of pVQS1 containing a quinolone resistance determinant from Salmonella enterica serovar Virchow associated with foreign travel [PDF]

, 2017
Objectives Nalidixic acid-resistant Salmonella enterica serovars Kentucky (n = 5) and Virchow (n = 6) cultured from individuals were investigated for the presence of plasmid-mediated quinolone resistance (PMQR) determinants.
Fanning, Séamus, Hächler, Herbert, Karczmarczyk, Maria, Stephan, Roger   +3 more
core