Results 91 to 100 of about 1,104,645 (398)

Multidrug resistance plasmids commonly reprogram the expression of metabolic genes in Escherichia coli

mSystems
Multidrug-resistant Escherichia coli is a leading cause of global mortality. Transfer of plasmids carrying genes encoding beta-lactamases, carbapenamases, and colistin resistance between lineages is driving the rising rates of hard-to-treat nosocomial ...
Rebecca J. Hall, Ann E. Snaith, Matthew J. N. Thomas, Michael A. Brockhurst, Alan McNally   +4 more
doaj   +1 more source

The Secretion of Toxins and Other Exoproteins of Cronobacter: Role in Virulence, Adaption, and Persistence

Microorganisms, 2020
Cronobacter species are considered an opportunistic group of foodborne pathogenic bacteria capable of causing both intestinal and systemic human disease.
Hyein Jang, Gopal R. Gopinath, Athmanya Eshwar, Shabarinath Srikumar, Scott Nguyen, Jayanthi Gangiredla, Isha R. Patel, Samantha B. Finkelstein, Flavia Negrete, JungHa Woo, YouYoung Lee, Séamus Fanning, Roger Stephan, Ben D. Tall, Angelika Lehner   +14 more
doaj   +1 more source

Integrative analysis of fitness and metabolic effects of plasmids in Pseudomonas aeruginosa PAO1

The ISME Journal, 2018
Horizontal gene transfer (HGT) mediated by the spread of plasmids fuels evolution in prokaryotes. Although plasmids provide bacteria with new adaptive genes, they also produce physiological alterations that often translate into a reduction in bacterial ...
Á. San Millán, Macarena Toll-Riera, Qin Qi, A. Betts, Richard J. Hopkinson, J. Mccullagh, R. MacLean   +6 more
semanticscholar   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Inference of plasmid copy number mean and noise from single cell gene expression data

, 2010
Plasmids are extra-chromosomal DNA molecules which code for their own replication. We previously reported a setup using genes coding for fluorescent proteins of two colors that allowed us, using a simple model, to extract the plasmid copy number noise in
Chatenay, Didier, Ghozzi, Stéphane, Ng, Jérôme Wong, Robert, Jérôme   +3 more
core   +1 more source

Gene doctoring: a method for recombineering in laboratory and pathogenic Escherichia coli strains [PDF]

, 2009
Background: Homologous recombination mediated by the lambda-Red genes is a common method for making chromosomal modifications in Escherichia coli.
Bingle, Lewis EH, Busby, Stephen J. W., Heurlier, Karin, Hobman, Jon L, Lee, David J, Pallen, Mark J., Penn, Charles W   +6 more
core   +5 more sources

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

Tracing lineage by phenotypic and genotypic markers in Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:- and Salmonella Typhimurium isolated in state of São Paulo, Brazil

Memorias do Instituto Oswaldo Cruz, 2009
Fifty-three Salmonella 1,4,[5],12:i:- and 45 Salmonella Typhimurium strains were characterised using phage typing, plasmid profiles and pulsed-field gel electrophoresis (PFGE) for comparison.
Ana T Tavechio, Sueli A Fernandes, Ângela CR Ghilardi, Geoff Soule, Rafiq Ahmed, Carmo EA Melles   +5 more
doaj   +1 more source

Shrimp AHPND-causing plasmids encoding the PirAB toxins as mediated by pirAB-Tn903 are prevalent in various Vibrio species

Scientific Reports, 2017
Acute hepatopancreatic necrosis disease (AHPND) is a newly emerging shrimp disease caused by pirAB toxins encoded by a plasmid found in Vibrio parahaemolyticus. The pirAB toxins are the homologs of the Photorhabdus insect-related (Pir) toxins.
Jinzhou Xiao, Liyuan Liu, Yiyun Ke, Xiefei Li, Yunfei Liu, Ying-jie Pan, Shuling Yan, Yongjie Wang   +7 more
semanticscholar   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

Molecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo, Carlos M. Martínez‐Cáceres, Manuel Bernabé‐García, Vicente Munitiz, David Ruiz de Angulo, Pascual Parrilla, Ángeles Ortiz, Luisa F. Martínez de Haro, María L. Cayuela   +8 more
wiley   +1 more source