Results 81 to 90 of about 647,445 (303)

Spatiotemporal and genomic analysis of carbapenem resistance elements in Enterobacterales from hospital inpatients and natural water ecosystems of an Irish city

Microbiology Spectrum
Carbapenemase-producing Enterobacterales (CPE) is a diverse group of often multidrug-resistant organisms. Surveillance and control of infections are complicated due to the inter-species spread of carbapenemase-encoding genes (CEGs) on mobile genetic ...
Mark Maguire, Carlos Serna, Natalia Montero Serra, Aneta Kovarova, Louise O’Connor, Niamh Cahill, Brigid Hooban, Niall DeLappe, Wendy Brennan, Genevieve Devane, Martin Cormican, Dearbháile Morris, Simone C. Coughlan, Georgios Miliotis, Bruno Gonzalez-Zorn, Liam P. Burke   +15 more
doaj   +1 more source

Molecular Characterization of Extensively Drug Resistant Salmonella Enterica Serovar Typhi Clinical Isolates from Lahore, Pakistan

Infection and Drug Resistance, 2023
Kokab Jabeen,1 Sidrah Saleem,1 Shah Jahan,1 Summiya Nizamudin,2 Faiqa Arshad,1 Zill-e Huma,1 Syed Mohsin Raza,3 Maria Mehmood,1 Muhammad Roman,1 Faiz Ul Haq1 1Department of Microbiology, University of Health Sciences, Lahore, Pakistan; 2Department of ...
Jabeen K, Saleem S, Jahan S, Nizamudin S, Arshad F, Huma ZE, Raza SM, Mehmood M, Roman M, Haq FU   +9 more
doaj  

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Plasmids. [PDF]

, 2012
Plasmids.
Adi Peleg (160360), Simi Koby (160357), Krishna C. Suddala (160366), Mark A. Saper (160377), Karthik Sathiyamoorthy (160368), Austin C. Johnson (160363), Bennett E. Smith (160372), Chen Nadler (160352), Ilan Rosenshine (43243)   +8 more
core   +3 more sources

Pathological Changes in Respiratory Part of Lungs White Mice with Experimental Plague

Эпидемиология и вакцинопрофилактика, 2015
The paper presents data on changes in the respiratory part of lungs of white mice with experimental plague caused by Yersinia рestis strains with different plasmid composition of Tuva and Gorno-Altaisk natural foci of plague and breeding clones ...
S. A. Vityazeva, T. P. Starovoitova, G. B. Mukhturgin, V. I. Dubrovina, S. V. Balakhonov   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

A hybrid plasmid formed by recombination of a virulence plasmid and a resistance plasmid in Klebsiella pneumoniae

Journal of Global Antimicrobial Resistance, 2020
The emergence of multidrug-resistant (MDR) and hypervirulent Klebsiella pneumoniae (hvKP) facilitates simultaneous dissemination of virulence and resistance in a single event, which poses serious threat to public health.This study characterized the multidrug-resistant and moderately virulent ST11 K64 K.
Xie, MM, Dong, N, Chen, KC, Yang, XM, Ye, LW, Chan, EWC, Zhang, R, Chen, S   +7 more
openaire   +4 more sources

IncHI1 plasmids, a dynamic link between resistance and pathogenicity [PDF]

, 2008
Plasmids of incompatibility group (Inc) HI1 are important vectors of antibiotic resistance in both of the major causal agents of enteric fever: Salmonella enterica subspecies enterica serovar Typhi and S. Paratyphi A. In S.
Minh-Duy Phan, John Wain
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Mobile genetic elements define the non-random structure of the Salmonella enterica serovar Typhi pangenome

mSystems
Bacterial relatedness measured using select chromosomal loci forms the basis of public health genomic surveillance. While approximating vertical evolution through this approach has proven exceptionally valuable for understanding pathogen dynamics, it ...
Arancha Peñil-Celis, Kaitlin A. Tagg, Hattie E. Webb, Santiago Redondo-Salvo, Louise Francois Watkins, Luis Vielva, Chelsey Griffin, Justin Y. Kim, Jason P. Folster, M. Pilar Garcillan-Barcia, Fernando de la Cruz   +10 more
doaj   +1 more source