Results 101 to 110 of about 899,588 (362)

Plasmid conjugation drives within-patient plasmid diversity

Microbial Genomics
AbstractPlasmids are well known vehicles of antimicrobial resistance (AMR) genes dissemination. Through conjugation, plasmid–encoded AMR genes are spread among neighbouring bacteria, irrespective of their strain or even their species. This process is very concerning from a public health perspective, as plasmid-borne AMR gene outbreaks are often not ...
Fan Grayson, Leo Loman, Toby Nonnenmacher, Diane Pople, Jack Pollard, Bharat Patel, David Williams, Luke Hounsome, Katie L. Hopkins, Julie V. Robotham, Alice Ledda   +10 more
openaire   +2 more sources

Plasmid Extraction (Plasmid Isolation) v1

, 2023
2023 NUS-Singapore iGEM team followed this protocol to isolate the plasmid from the cells.
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Plasmid diversity of Serratia marcescens and Klebsiella pneumoniae isolates involved in two carbapenem-resistant Enterobacteriaceae outbreaks in a Swiss hospital

Microbiology Spectrum
This study investigates two distinct carbapenemase-producing Enterobacteriaceae outbreaks involving patients and contaminated sink traps at the University Hospital of Lausanne.
Florian Mauffrey, Claire Bertelli, Gilbert Greub, Bruno Grandbastien, Laurence Senn, Dominique S. Blanc   +5 more
doaj   +1 more source

Long read genome assemblers struggle with small plasmids

, 2023
Jared Johnson, Marty Soehnlen, Heather M. Blankenship   +2 more
openalex   +1 more source

\u3cem\u3eRhizobium phaseoli\u3c/em\u3e Symbiotic Mutants with Transposon Tn5 Insertions [PDF]

, 1984
Rhizobium phaseoli CFN42 DNA was mutated by random insertion of Tn5 from suicide plasmid pJB4JI to obtain independently arising strains that were defective in symbiosis with Phaseolus vulgaris but grew normally outside the plant.
Cevallos, Miguel A., Fernandez, Leonor, Leemans, Jan, Noel, K. Dale, Sanchez, Araceli   +4 more
core   +1 more source

Rapid compensatory evolution promotes the survival of conjugative plasmids [PDF]

, 2016
Conjugative plasmids play a vital role in bacterial adaptation through horizontal gene transfer. Explaining how plasmids persist in host populations however is difficult, given the high costs often associated with plasmid carriage. Compensatory evolution
Brockhurst, Michael A., Dytham, Calvin, Guymer, David, Hall, James P. J., Harrison, Ellie, Paterson, Steve, Spiers, Andrew J.   +6 more
core   +4 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Self-Documenting Plasmids

Trends in Biotechnology
SummaryPlasmids are the workhorse of biotechnology. These small DNA molecules are used to produce recombinant proteins and to engineer living organisms. They can be regarded as the blueprints of many biotechnology products. It is, therefore, critical to ensure that the sequences of these DNA molecules match their intended designs.
Sarah I. Hernandez, Samuel J. Peccoud, Casey-Tyler Berezin, Jean Peccoud   +3 more
openaire   +4 more sources

Inference of plasmid copy number mean and noise from single cell gene expression data

, 2010
Plasmids are extra-chromosomal DNA molecules which code for their own replication. We previously reported a setup using genes coding for fluorescent proteins of two colors that allowed us, using a simple model, to extract the plasmid copy number noise in
Chatenay, Didier, Ghozzi, Stéphane, Ng, Jérôme Wong, Robert, Jérôme   +3 more
core   +1 more source