Results 121 to 130 of about 1,084,010 (405)

Plasmid interference for curing antibiotic resistance plasmids in vivo [PDF]

PLOS ONE, 2017
Antibiotic resistance increases the likelihood of death from infection by common pathogens such as Escherichia coli and Klebsiella pneumoniae in developed and developing countries alike. Most important modern antibiotic resistance genes spread between such species on self-transmissible (conjugative) plasmids. These plasmids are traditionally grouped on
M. Kamruzzaman, Sally R. Partridge, Sally R. Partridge, Jonathan R. Iredell, Jonathan R. Iredell, Shereen Shoma, Christopher M. Thomas   +6 more
openaire   +4 more sources

Recycler: an algorithm for detecting plasmids from de novo assembly graphs

bioRxiv, 2016
Plasmids are central contributors to microbial evolution and genome innovation. Recently, they have been found to have important roles in antibiotic resistance and in affecting production of metabolites used in industrial and agricultural applications ...
Roye Rozov, A. Kav, David Bogumil, N. Shterzer, E. Halperin, I. Mizrahi, R. Shamir   +6 more
semanticscholar   +1 more source

pFAR plasmids: New Eukaryotic Expression Vectors for Gene Therapy, devoid of Antibiotic Resistance Markers [PDF]

, 2008
Efficient production of eukaryotic expression vectors requires the selection of plasmid-containing bacteria. To avoid the risk of dissemination of antibiotic resistance markers, we developed a new system to produce a family of plasmids Free of Antibiotic
Corinne Marie, Daniel Scherman, Gaelle Vandermeulen, Magali Richard, Mickael Quiviger, Veronique Preat   +5 more
core   +1 more source

The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict [PDF]

, 2012
Bacterial genomes commonly contain ‘addiction’ gene complexes that code for both a toxin and a corresponding antitoxin. As long as both genes are expressed, cells carrying the complex can remain healthy.
Brown, Sam P., Heinemann, Jack A., Rankin, Daniel J., Turner, Leighton A.   +3 more
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Genomics of microbial plasmids: classification and identification based on replication and transfer systems and host taxonomy

Frontiers in Microbiology, 2015
Plasmids are important “vehicles” for the communication of genetic information between bacteria. The exchange of plasmids transmits pathogenically and environmentally relevant traits to the host bacteria, promoting their rapid evolution and adaptation to
M. Shintani, Z. Sanchez, K. Kimbara
semanticscholar   +1 more source

Cointegration as a mechanism for the evolution of a KPC-producing multidrug resistance plasmid in Proteus mirabilis

Emerging Microbes and Infections, 2020
The incidence and transmission of Klebsiella pneumoniae carbapenemase (KPC) producing plasmids have been well documented. However, the evolutionary dynamics of KPC plasmids and their fitness costs are not well characterized.
Xiaoting Hua, Linyue Zhang, Robert A. Moran, Qingye Xu, Long Sun, Willem van Schaik, Yunsong Yu   +6 more
doaj   +1 more source

Organization of aerobactin, hemolysin, and antibacterial resistance genes in lactose negative Escherichia coli strains of serotype O4 isolated from children with dhiarrea [PDF]

, 1992
Epidemiologically related, non-lactose-fermenting (NLF) Escherichia coli strains of serotype O4 have been isolated at a high frequency from children with diarrhea in Somalia (M. Nicoletti, F. Superti, C. Conti, A. Calconi, and C. Zagaglia, J.
Calconi, Attilio, Casalino, M., Colonna, Bianca, Fradiani, PIERA ASSUNTA, Nicoletti, M., Ranucci, L.   +5 more
core   +1 more source

How the other half lives: CRISPR-Cas's influence on bacteriophages

, 2017
CRISPR-Cas is a genetic adaptive immune system unique to prokaryotic cells used to combat phage and plasmid threats. The host cell adapts by incorporating DNA sequences from invading phages or plasmids into its CRISPR locus as spacers.
AE Briner, AF Andersson, BR Levin, C Pourcel, CL Sun, D Bhaya, E Pennisi, E Scarpellini, EV Koonin, FS Berezovskaya, GW Tyson, H Deveau, H Deveau, I Yosef, IN Berezovsky, J He, J Iranzo, J Mahony, JF Heidelberg, JM Peters, JO Haerter, KD Seed, KL Maxwell, LA Marraffini, LM Childs, M Sebaihia, P Han, P Horvath, P Horvath, PD Hsu, R Barrangou, R Lillestøl, R Sorek, S Al-Attar, S Minot, W Jiang   +35 more
core   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source