Results 131 to 140 of about 672,641 (302)

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Comparative genomics of five different resistance plasmids coexisting in a clinical multi-drug resistant Citrobacter freundii isolate

, 2018
Jing Ouyang,1,2,* Fengjun Sun,1,* Dongsheng Zhou,3 Jiao Feng,3 Zhe Zhan,3 Zhijian Xiong,4 Bo Yang,1 Zhirui Liu,1 Tingbo Li,1 Yigang Tong,3 Peiyuan Xia1 1Department of Pharmacy, Southwest Hospital, The Third Military Medical University, Chongqing 400038 ...
Xiong Z, Liu Z, Feng J, Li T, Zhou D, Xia P, Sun F, Yang B, Ouyang J, Tong Y, Zhan Z   +10 more
core  

Expanding the diversity of origin of transfer-containing sequences in mobilizable plasmids

International audienceConjugative plasmids are important drivers of bacterial evolution. Most plasmids lack genes for conjugation and characterized origins of transfer (oriT), which has hampered our understanding of plasmid mobility.
Ares-Arroyo, Manuel, Nucci, Amandine, Rocha, Eduardo   +2 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Role of Mobilome in Carbapenem Resistance

Antibiotics
Growing resistance to carbapenem antibiotics is a major public health problem as these antibiotics are considered the last line of therapy for infections caused by multidrug-resistant (MDR) Gram-negative bacteria. The rapid emergence and dissemination of
Laiba Hassan, Muhammad Ali Syed, Binghuai Lu, Jiankang Zhao, Bin Cao   +4 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Fingerprinting and sequence homology of plasmids from different virulent strains of Agrobacterium rhizogenes

, 1982
[no abstract ...
COSTANTINO, Paolo, G. Battistoni, P. Agrobacterium Rhizogenes Regions Of Homology Between Tumorigenic Plasmids From, Tumefaciens Agrobacterium, RISULEO, Gianfranco   +4 more
core  

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

First Report and Comprehensive Risk Index of bla_IMP-1-Harboring Brucella anthropi in Municipal Wastewater-Irrigated Soil

Microorganisms
Brucella anthropi is an emerging opportunistic pathogen characterized by intrinsic resistance to most β-lactams. However, the acquisition of carbapenem resistance in this species has rarely been documented in environmental, animal, or clinical settings ...
Ling Zhao, Yanhao Wu, Runze Xu, Xuewen Li   +3 more
doaj   +1 more source