Results 231 to 240 of about 672,641 (302)

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Genomic analysis reveals close genetic similarity between ESBL and other β-lactamase-producing E. coli isolates from humans and dogs, suggesting potential for inter-species transmission. [PDF]

BMC Genomics
Whitehead-Tillery CE, Waite SE, Durand-Piña GAE, Green EK, Bell JA, Zhang L, Mansfield LS.   +6 more
europepmc   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

A user-friendly strategy to engineer tailored intermediate strains for overcoming combined type I and type II restriction-modification barriers in <i>Staphylococcus aureus</i>. [PDF]

Synth Syst Biotechnol
Zheng Y, Li C, Huang X, Shou X, Su R, Zhang J, Hu Q, Shang W, Rao X, Zhou R, Jiang XR.   +10 more
europepmc   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Fluorescence-Activated Cell Sorting Enables Rapid Screening of RNA Polymerase-Promoter Interaction in E. coli. [PDF]

Biochemistry
Göldel L, Krafczyk R, Rathberger R, Brück T, Richter H.   +4 more
europepmc   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Characterization of the conjugative modules of the pRAS4 plasmid of <i>Aeromonas salmonicida</i> reveals an environmental lineage. [PDF]

Front Microbiol
Dahal SP, Dubey S, Munang'andu HM, Sørum H.   +3 more
europepmc   +1 more source

Genetic Elements Associated with the Acquired Resistome of the Gut Microbiota in a Broiler Rooster Flock in Hungary. [PDF]

Animals (Basel)
Kiss J, Libisch B, Ozoaduche CL, Fébel H, Rasschaert G, Lambrecht E, Heyndrickx M, Szabó M, Keresztény T, Posta K, Olasz F.   +10 more
europepmc   +1 more source

Scalable Production of Transfection-Grade Plasmid DNA by Liquid-Liquid Extraction Without Chromatography: Application to CAR-T Vector Packaging. [PDF]

Bioengineering (Basel)
Nigmatulla G, Kydyrbayeva A, Kulatay T, Zauatbayeva G, Ingirbay B, Sagyndykova L, Keyer V, Zharlyganova D, Zhumabekova M, Shustov AV.   +9 more
europepmc   +1 more source