Results 241 to 250 of about 842,970 (314)

Microplastics enhance the risk of cross-genus dissemination of carbapenemase resistance plasmids in ICU patients. [PDF]

Front Cell Infect Microbiol
Ni Y, Zhang J, Peng C, Yang Y, Lin Y, Li Z.   +5 more
europepmc   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Author Correction: A global soil plasmidome resource unveils functional and ecological roles of plasmids in soil microbiomes. [PDF]

Nat Commun
Fiamenghi MB, Camargo AP, Ivanova NN, Graham EB, Wu R, Hofmockel KS, Kyrpides NC.   +6 more
europepmc   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

CRISPR-Cas is beneficial in plasmid competition, but limited by competitor toxin-antitoxin activity when horizontally transferred. [PDF]

PLoS Biol
Sünderhauf D, Ringger JR, Payne LJ, Pinilla-Redondo R, Gaze WH, Brown SP, van Houte S.   +6 more
europepmc   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Dissemination of a <i>bla</i> _{NDM - 1}-harboring IncH plasmid associated with concurrent ST30 <i>Klebsiella pneumoniae</i> and ST2 <i>Klebsiella oxytoca</i> outbreaks in a Chinese neonatal unit. [PDF]

Front Microbiol
Dong D, Zou L, Liu Z, Jia N, Liu Y, Zhao H, Zhu Y.   +6 more
europepmc   +1 more source

Isolation, cloning and characterisation of motifs containing (GA/TC)n rpeeats from vetch, Vicia bithynica [PDF]

, 2004
Bowater, Richard, Parniewski, Pawel, Sakowicz, Tomasz   +2 more
core  

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

A One Health Perspective on the Plasmid Backbone Preference and Evolutionary Adaptation of <i>tmexCD-toprJ</i> in <i>Klebsiella spp</i>. [PDF]

Infect Drug Resist
Jiang X, Liu F, Chai J, Li X, Li Y, Fu S, Li Y.   +6 more
europepmc   +1 more source