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Extensively Drug-Resistant ST16 <i>Klebsiella pneumoniae</i> Co-Harboring <i>bla</i> _KPC-2, <i>bla</i> _OXA-181, and Chromosomal <i>bla</i> _NDM-4: Genomic Features and Therapeutic Challenges. [PDF]

Infect Drug Resist
Li Y, Li H, Xu X, Ma J, Wang H, Sun S, Wang W.   +6 more
europepmc   +1 more source

OXA-181 transmission confounded by a stable IncX3 plasmid

Lee TSE, Nguyen L, Forde BM, Maidment T, Ye S, Henderson A, Playford EG, Runnegar N, Henderson B, Watson C, Lindsay M, Bursle E, Douglas J, Hume J, Paterson DL, Kidd T, Graves B, Hume A, Hall MB, Schembri MA, Beatson SA, Harris PN, Roberts LW.   +22 more
europepmc   +1 more source

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Plasmid evolution

Current Biology, 2020
Plasmids are genetic elements that colonize and replicate in prokaryotic cells (Box 1). They are considered a major driving force of prokaryote evolution, as they can migrate between populations, making them potent agents of lateral DNA transfer and microbial warfare.
Tanita, Wein, Tal, Dagan
openaire   +2 more sources

Stop That Plasmid

Nature Reviews Microbiology, 2020
This study developed an assay to screen for drugs that inhibit transfer of antimicrobial resistance plasmids between bacteria.
Ursula Hofer
exaly   +3 more sources

Ti plasmids of Agrobacterium as conjugative plasmids

Nature, 1977
THE relationship of the plant-oncogenic properties of Agrobacterium tumefaciens to the presence in these strains of large plasmids (the Ti plasmids) has now been convincingly demonstrated in several ways: oncogenic strains cured of the Ti plasmid lose their oncogenicity irreversibly1–3; transfer of Ti plasmids to non-oncogenic plasmidless strains ...
C, Genetello, N, Van Larebeke, M, Holsters, A, De Picker, M, Van Montagu, J, Schell   +5 more
openaire   +2 more sources

Plasmid Profile Typing and Plasmid Fingerprinting

2003
Plasmids are extra-chromosomal molecules of deoxyribonucleic acid (DNA) capable of autonomous replication. Such molecules have been identified in many bacterial genera and usually exist as covalently closed circular (CCC) molecules. Plasmids range in size from less than one megaDalton (MDa) to several hundred MDa.
E J, Threlfall, N, Woodford
openaire   +2 more sources

Macroevolution of plasmids: A model for plasmid speciation

Journal of Theoretical Biology, 1992
A new evolutionary model for diversification in plasmid incompatibility groups (plasmid speciation) is suggested. The model is based on the formation of plasmid cointegrates from two compatible plasmids. The existence of plasmid cointegrates is well known, however, their potential key role in plasmid macroevolution has not yet been recognized.
openaire   +2 more sources

Plasmid Vectors

2003
Genetic manipulation of mycobacteria has historically been difficult. This is in large part due to the impenetrable nature of the cell wall, resulting in difficulty both in introducing DNA into the bacterium and subsequent isolation of intact plasmid DNA.
N, Casali, S, Ehrt
openaire   +2 more sources