Results 51 to 60 of about 890,612 (362)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Vancomycin Resistance in Enterococcus faecium from the Dallas, Texas, Area Is Conferred Predominantly on pRUM-Like Plasmids

mSphere, 2023
Vancomycin-resistant E. faecium (VREfm) is a significant public health concern because of limited treatment options. Genomic surveillance can be used to monitor VREfm transmission and evolution.
Moutusee Islam, Belle Sharon, Ada Abaragu, Harita Sistu, Ronda L. Akins, Kelli Palmer   +5 more
doaj   +1 more source

PifC and Osa, Plasmid Weapons against Rival Conjugative Coupling Proteins [PDF]

, 2017
Bacteria display a variety of mechanisms to control plasmid conjugation. Among them, fertility inhibition (FI) systems prevent conjugation of co-resident plasmids within donor cells.
Brown, Cabezon, Cabezon, Cascales, Chandler, Christie, Close, Coetzee, Datta, Datta, de Toro, del Campo, Derbyshire, Eddy, Edgar, Elhai, Fernandez-Lopez, Fernandez-Lopez, Fong, Frost, Garcillan-Barcia, Garcillan-Barcia, Gasson, Gasson, Getino, Golebiewski, Goncharoff, Gotz, Grant, Guglielmini, Guglielmini, Guzman, Kolter, Komano, Langer, Llosa, Maindola, Marraffini, Mazodier, Meynell, Miller, Norman, Olsen, Posfai, Revilla, Santini, Sorensen, Tanimoto, Taylor, Thorsted, van Putten, Van Rensburg, Waters, Whelan, Wilkins, Winans, Yoshioka   +56 more
core   +3 more sources

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Plasmid DNA for Therapeutic Applications in Cancer

Pharmaceutics, 2022
Recently, the interest in using nucleic acids for therapeutic applications has been increasing. DNA molecules can be manipulated to express a gene of interest for gene therapy applications or vaccine development.
David Hernán Martínez-Puente, José Juan Pérez-Trujillo, Laura Mireya Zavala-Flores, Aracely García-García, Arnulfo Villanueva-Olivo, Humberto Rodríguez-Rocha, Jesús Valdés, Odila Saucedo-Cárdenas, Roberto Montes de Oca-Luna, María de Jesús Loera-Arias   +9 more
doaj   +1 more source

What traits are carried on mobile genetic elements, and why? [PDF]

, 2010
Although similar to any other organism, prokaryotes can transfer genes vertically from mother cell to daughter cell, they can also exchange certain genes horizontally.
A Gardner, A Gardner, A Gardner, A Gardner, A Gardner, A Gardner, A Mochizuki, A Norman, A Philppon, A Wagner, AD O’Brien, AS Griffin, B Sanchez, BJ Crespi, BK Kozlowicz, BMM Ahmer, BR Levin, C Buchrieser, CE White, CF Amabile-Cuevas, CG Kurland, CM Thomas, CM Yates, CT Bergstrom, D Gevers, D J Rankin, DJ Rankin, DM Livermore, E Cascales, E Cascales, E Lerat, E P C Rocha, E Polzleitner, ES Egan, F Bushman, F de la Cruz, F Delsuc, F Dionisio, F Dionisio, F Harrison, F Rousset, FM Stewart, FR Slater, G Gil, G Hardin, GA Dykes, H Knothe, H Ochman, I Chen, I Kobayashi, I Rasched, J Hacker, J Lederberg, J Paulsson, J Smith, J Zupan, JB Ferdy, JB Xavier, JC Diaz Ricci, JE Bouma, JL Martinez, JL Martínez, JL Sachs, JL Sachs, JR van der Ploeg, K Lee, KM Oliver, KR Foster, KR Foster, KR Foster, L Buts, L Chao, L Keller, L Lehmann, L Lehmann, L Riboli-Sasco, L Van Melderen, LE Orgel, LJ Johnson, LN Lili, LS Frost, M Achtman, M Ackermann, M Touchon, MA Riley, MI Bahl, MI Bahl, MK Waldor, MP Nuti, N Goldenfeld, ND Zinder, PB Rainey, PE Turner, PE Turner, R Barrangou, R Korona, RD Magnuson, RE Fox, RJ Ellis, RJF Haft, RM Anderson, RM Anderson, RM May, S Alizon, S P Brown, SA West, SA West, SA West, SA West, SC Slater, SJ Sorensen, SM Faruque, SP Brown, SP Brown, SP Brown, SP Brown, SR Bordenstein, T Nogueira, TF Cooper, TF Cooper, VL Arcus, WD Hamilton, WD Hamilton, WG Eberhard   +123 more
core   +3 more sources

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

Role of plasmids in antibiotic resistance in clinical infections and implications for epidemiological surveillance: a review

All Life
The global upsurge in antibiotic resistant bacteria (ARB) is putting immense pressure on healthcare. The spreading of antimicrobial resistance is facilitated by mobile genetic elements, most especially plasmids.
Ayodele Oluwaseun Ajayi, Olajide Joseph Akinjogunla, Adebowale Toba Odeyemi, Akinyomade Oladipo Owolabi   +3 more
doaj   +1 more source

Organization of aerobactin, hemolysin, and antibacterial resistance genes in lactose negative Escherichia coli strains of serotype O4 isolated from children with dhiarrea [PDF]

, 1992
Epidemiologically related, non-lactose-fermenting (NLF) Escherichia coli strains of serotype O4 have been isolated at a high frequency from children with diarrhea in Somalia (M. Nicoletti, F. Superti, C. Conti, A. Calconi, and C. Zagaglia, J.
Calconi, Attilio, Casalino, M., Colonna, Bianca, Fradiani, PIERA ASSUNTA, Nicoletti, M., Ranucci, L.   +5 more
core   +1 more source

Precise targeted integration by a chimaeric transposase zinc-finger fusion protein [PDF]

, 2010
Transposons of the Tc1/mariner family have been used to integrate foreign DNA stably into the genome of a large variety of different cell types and organisms.
Abdel-Meguid, Amann, Amy L. Bednarz, Beerli, Boyd, Bryan, Bushman, Bushman, Ciuffi, Cockrell, Collins, Daniel, Emmons, Feng, Goulaouic, Hacein-Bey-Abina, Isalan, Ivics, Ivics, Ivics, Ivics, Ivics, Kaneko, Kaneko, Katz, Lampe, Lampe, Lohe, Maeder, Maragathavally, Ni, Pabo, Pavletich, Plasterk, Richardson, Rimphanitchayakit, Sean D. Colloms, Simons, Sorrell, Suckow, Szabo, Tan, Tan, Thomas, Urasaki, Voigt, Wilson, Xiaofeng Feng, Yant, Zhu   +49 more
core   +3 more sources