Results 121 to 130 of about 105,823 (139)

The Holy Grail of cardiology?

Experimental Physiology, EarlyView.
Richard Godfrey
wiley   +1 more source

Hydrophobin‐Coated Echogenic Microbubbles for Molecular Targeting of Tumor Cells

Advanced Science, Volume 12, Issue 22, June 12, 2025.
Echogenic microbubbles based on hydrophobin and corresponding fusion protein (HFBI‐domZ) are developed as contrast agents for cancer diagnostics. Hydrophobin provides high stabilization of encapsulated perfluoro‐n‐butane, and fusion proteins allow further versatile functionalization with antibodies. In‐vitro experiments indicate that these microbubbles
Hedar H. Al‐Terke, Grégory Beaune, Muhammad Junaid, Jani Seitsonen, Arja Paananen, Pierangelo Metrangolo, Jaakko V. I. Timonen, Jussi Joensuu, Robin H. A. Ras   +8 more
wiley   +1 more source

Inhibiting the Histone Demethylase Kdm4a Restrains Cardiac Fibrosis After Myocardial Infarction by Promoting Autophagy in Premature Senescent Fibroblasts

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Kdm4a downregulation restrains excessive cardiac interstitial fibrosis and remodeling by depressing the premature senescence of fibroblasts in the advanced stage after MI but does not affect early ventricular rupture. It verified that Kdm4a downregulation promotes autophagy in premature senescent fibroblasts by increasing the H3K9m3 modification of the
Ming Jin, Chuling Li, Zhaoyi Wu, Zhenquan Tang, Jingfang Xie, Guoquan Wei, Zhiwen Yang, Senlin Huang, Yijin Chen, Xinzhong Li, Yanmei Chen, Wangjun Liao, Yulin Liao, Guojun Chen, Hao Zheng, Jianping Bin   +15 more
wiley   +1 more source

LC‐MS/MS proteomics identifies plasma proteins related to cognition over 9‐year follow‐up

Alzheimer's &Dementia, Volume 21, Issue 6, June 2025.
Abstract INTRODUCTION This project identified plasma proteins predictive of cognitive decline across a robust neuropsychological protocol over a 9‐year period. METHODS Vanderbilt Memory and Aging Project participants (n = 336, 73 ± 7 years, 59% male, 87% non‐Hispanic White, 10% Black/African American) underwent blood draw for baseline plasma protein ...
Hailey A. Adegboye, Khiry L. Patterson, Julia Libby, Yunyi Sun, Panpan Zhang, Dandan Liu, W. Hudson Robb, Amalia J. Peterson, Keith R. Cole, Albert B. Arul, Nekesa C. Oliver, Marsalas D. Whitaker, Kimberly R. Pechman, Logan Dumitrescu, Corey J. Bolton, Kaj Blennow, Henrik Zetterberg, Timothy J. Hohman, Renã A. S. Robinson, Angela L. Jefferson   +19 more
wiley   +1 more source

Intravenous Thrombolysis in Patients Taking Direct Oral Anticoagulation Treatment Before Stroke Onset: Results from the Safe Implementations of Treatments in Stroke International Stroke Registry

Annals of Neurology, Volume 97, Issue 6, Page 1205-1214, June 2025.
Objectives Intravenous thrombolysis (IVT) is contraindicated for acute ischemic stroke (AIS) patients taking direct oral anticoagulants (DOACs) within 48 hours before index stroke. Limited data exist on off‐label use of IVT for these patients. We compared the safety and outcomes of IVT in AIS patients with DOAC treatment and patients with no OAC before
Marius Matusevicius, Malin Säflund, Maurizio Balestrino, Manuel Cappellari, Delfina Ferrandi, Abdoreza Ghoreishi, André Peeters, Viiu‐Marika Rand, Manuela De Michele, Aleksandras Vilionskis, Andrea Zini, Niaz Ahmed   +11 more
wiley   +1 more source

Tirofiban Combination Therapy for Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis

Brain and Behavior, Volume 15, Issue 6, June 2025.
ABSTRACT Introduction Acute ischemic stroke (AIS) is a leading cause of morbidity and mortality globally. Standard antiplatelet therapies, while partially effective, do not fully inhibit all pathways of platelet aggregation, leaving patients at risk of recurrent thrombotic events. Tirofiban, a glycoprotein IIb/IIIa receptor inhibitor, has shown promise
Abdullah Bin Kamran, Ahmed Bazil Bin Khalil, Ayesha Muhammad, Hira Arshad, Fatima Nazir, Muhammad Mateen Ali, M. Mairaj Umar, Muhammad Farhan, Sudhair Alam, Javed Iqbal   +9 more
wiley   +1 more source

The Relationship Between Body Mass Index and Recurrence Risk of Stroke: A Systematic Review and Dose–Response Meta‑Analysis

Brain and Behavior, Volume 15, Issue 6, June 2025.
The obesity paradox can be extended to stroke recurrence. A 2% reduction in recurrence risk of stroke per 1‐unit increase in BMI. ABSTRACT Objective To explore the relationship between body mass index (BMI) and the recurrence risk of stroke. Methods We searched databases, including the Web of Science, Cochrane Library, Embase, PubMed, Chinese ...
Qiuxia Qian, Yuting Zhao, Xin Fan, Jialu Li, Jianxun Cao, Mengyu Yang, Longchun Hua, Xingxia Zhang, Ailing Yang, Fengwa Zhang, Yuxia Ma   +10 more
wiley   +1 more source

Massive Acute Thrombosis of a Mechanical Mitral Valve in a Young Patient on Acenocoumarin: A Case Report Comparing Surgical and Thrombolytic Approaches

Clinical Case Reports, Volume 13, Issue 6, June 2025.
ABSTRACT Obstructive mechanical mitral valve thrombosis is a life‐threatening emergency requiring urgent intervention. Surgery is often first‐line; thrombolysis may be considered in high‐risk cases. A multidisciplinary approach is essential to balance thromboembolic and bleeding risks, emphasizing early recognition, optimized anticoagulation, and ...
Said Khallikane, Bassam Bencharfa, Noureddine Atmani, Abdessamad Abdou, Ayoub Belhadj, Younes Aissaoui   +5 more
wiley   +1 more source

Contemporary Perspectives on Chronic Renal Disorders

Chronic Diseases and Translational Medicine, Volume 11, Issue 2, Page 89-104, June 2025.
ABSTRACT The prevalence of renal diseases and its associated burden on healthcare have tremendously risen in the past few years. From simple markers assessing kidney function, current renal research delves into understanding the diseases at the cellular and molecular levels and not just at treating, but at improving quality of life, arresting ...
Deenadhayalan Ashok, Poornima Ajay Manjrekar, Bhushan C. Shetty, Sujina S. S, Rukmini Mysore Srikantiah, Sowndarya Kollampare   +5 more
wiley   +1 more source

New horizons in the pharmacological management of venous thromboembolism

HemaSphere, Volume 9, Issue 6, June 2025.
Abstract Many patients suffer from venous thromboembolism (VTE) and its consequences. Despite substantial advancements with the introduction of direct oral anticoagulants (DOACs), patients and clinicians still encounter challenges in the acute and long‐term management of VTE, such as recurrent events, anticoagulant‐related bleeding complications, and ...
Andreas Verstraete, Quentin Van Thillo, Thomas Vanassche, Peter Verhamme   +3 more
wiley   +1 more source