Results 331 to 340 of about 315,782 (393)

Plasminogen activator inhibitors

Trends in Cardiovascular Medicine, 1991
Plasminogen activator inhibitors (PAIs) regulate plasminogen activation in normal and pathologic processes. Plasminogen activator inhibitor 1 (PAI-1) is the major physiologic inhibitor of both tissue-type and urokinase-type plasminogen activators. It is a highly regulated single-chain glycoprotein, whose overexpression in vivo impairs the fibrinolytic ...
J, Schneiderman, D J, Loskutoff
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Annexin II: a plasminogen-plasminogen activator co-receptor

Frontiers in Bioscience, 2002
Fibrinolysis is a precisely orchestrated process in which fibrin-containing thrombi are solubilized. Several receptors regulate this process by localizing proteolytic activity to the cell surface. One such receptor is annexin II, a calcium and phospholipid-binding protein.
Jiyun, Kim, Katherine A, Hajjar
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Activation of Val442-plasminogen (mini-plasminogen) by urokinase, streptokinase and tissue plasminogen activator

Thrombosis Research, 1988
Glu-plasminogen (Glu-plg), Lys-plg and Val442-plg (mini-plg) were activated by urokinase (UK), streptokinase (SK) or tissue plasminogen activator (t-PA). Their activation rates were kinetically analyzed. UK activated Lys-plg with smaller Km and nearly identical Vmax as Glu-plg.
A, Takada, Y, Takada, Y, Sugawara
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Interaction of heparin with plasminogen activators and plasminogen: effects on the activation of plasminogen

Biochemistry, 1986
The amidolytic plasmin activity of a mixture of tissue plasminogen activator (tPA) and plasminogen is enhanced by heparin at therapeutic concentrations. Heparin also increases the activity in mixtures of urokinase-type plasminogen activator (uPA) and plasminogen but has no effect on streptokinase or plasmin. Direct analyses of plasminogen activation by
P, Andrade-Gordon, S, Strickland
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Fluorescence polarization assay of plasmin, plasminogen, and plasminogen activator

Analytical Biochemistry, 1980
Abstract We describe two assay methods for plasminogen activator (urokinase) employing the fluorescence polarization technique. One method utilizes fluoroscein isothiocyanate-labeled plasminogen as the substrate for urokinase (direct method), and the other utilizes the new plasmin generated from plasminogen by urokinase, for which fluoroscein ...
K, Kinoshita, H, Maeda, Y, Hinuma
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STUDIES ON PLASMINOGEN: I. FURTHER PURIFICATION OF BOVINE PLASMINOGEN

Canadian Journal of Biochemistry and Physiology, 1961
Crude bovine plasminogen, prepared from bovine serum by 30% saturation with ammonium sulphate, was partially purified by isoelectric precipitation at pH 5.3, then purified by chromatography on columns of diethylaminoethyl-cellulose. Additional purification of the column product was obtained by precipitation of plasminogen from solution with potassium ...
E R, COLE, E T, MERTZ
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Plasminogen activator / plasminogen activator inhibitors in ovarian physiology

Frontiers in Bioscience, 2004
The target extracellular matrix (ECM) degradation generated by plasminogen activator (PA) and regulated by plasminogen activator inhibitor (PAI) is an event that affects a wide variety of physiological and pathological processes in the ovary. Studies carried out over the past 25 years in a number of laboratories have elucidated some of the biochemical ...
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Glycated Proteins Modulate Tissue–Plasminogen Activator-Catalyzed Plasminogen Activation

Biochemical and Biophysical Research Communications, 1997
Plasminogen activation by tissue-plasminogen activator (t-PA) is accelerated by the presence of a macromolecular surface, which acts as a template that brings enzyme and substrate in close proximity. Modification of lysine residues, which are important for this template function, occurs in diabetic patients as a consequence of glycation of proteins. In
I W, Bobbink, W L, Tekelenburg, J J, Sixma, H C, de Boer, J D, Banga, P G, de Groot   +5 more
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Plasminogen.

Brain research. Gene expression patterns, 2007
Plasminogen activator inhibitor-2 (PAI-2) specifically inhibits plasminogen activators, extracellular fibrinolytic serine proteases that are also implicated in brain plasticity and toxicity. Primarily localized intracellularly, PAI-2 is thought to also counteract apoptosis mediated by a currently undefined intracellular protease.
R, Sharon, R, Abramovitz, R, Miskin
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Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS)

Journal of the American Medical Association (JAMA), 1995
W. Hacke, M. Kaste, C. Fieschi, D. Toni, E. Lesaffre, R. von Kummer, G. Boysen, E. Bluhmki, G. Höxter, M. Mahagne   +9 more
semanticscholar   +1 more source