Results 101 to 110 of about 3,602,430 (295)

Differential effects of tissue plasminogen activator and streptokinase on infarct size and on rate of enzyme release: influence of early infarct related artery patency: The GUSTO Enzyme Substudy [PDF]

, 2017
Background The recent international GUSTO trial of 41 021 patients with acute myocardial infarction demonstrated improved 90-mm infarct related artery patency as well as reduced mortality in patients treated with an accelerated regimen of tissue ...
Baardman, T., Grollier, G., Hermens, W. Th, Lenderink, T., Molhoek, G. P., Pfisterer, M., Simoons, M. L.   +6 more
core  

Prognostic significance of uPA/PAI-1 level, HER2 status, and traditional histologic factors for survival in node-negative breast cancer patients

Radiology and Oncology, 2016
The association of HER2 status with urokinase plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1) levels raises the question whether uPA/PAI-1 level carries additional clinically relevant prognostic information independently from ...
Dovnik Nina Fokter, Takac Iztok
doaj   +1 more source

Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling. [PDF]

, 2015
In glioblastoma (GBM), the EGF receptor (EGFR) and Src family kinases (SFKs) contribute to an aggressive phenotype. EGFR may be targeted therapeutically; however, resistance to EGFR-targeting drugs such as Erlotinib and Gefitinib develops quickly.
Cavenee, WK, Furnari, FB, Gonias, SL, Hu, J, Muller, KA, VandenBerg, SR   +5 more
core  

Plasminogen Activator Inhibitor-1 From Bone Marrow–Derived Cells Suppresses Neointimal Formation After Vascular Injury in Mice [PDF]

, 2006
Katrin Schäfer, Marco R. Schroeter, Claudia Dellas, Miriam Puls, Mirko Nitsche, Elisabeth H. Weiss, Gerd Hasenfuß, Stavros Konstantinides   +7 more
openalex   +1 more source

Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury. [PDF]

, 2019
The goal of stem cell therapy for spinal cord injury (SCI) is to restore motor function without exacerbating pain. Induced pluripotent stem cells (iPSC) may be administered by autologous transplantation, avoiding immunologic challenges.
Brifault, Coralie, Campana, Wendy M, Gonias, Steven L, Jeziorski, Jacob J, Kim, John H, Kwon, HyoJun, Mesci, Pinar, Muotri, Alysson R, Nasamran, Chanond, Ohtori, Seiji, Shiga, Akina, Shiga, Yasuhiro   +11 more
core  

MRI predicts area of increased plasminogen activation in permanent focal cerebral ischemia [PDF]

, 2001
Thomas Pfefferkorn, Christoph Wießner, Peter R. Allegrini, Martin Liebetrau, Christian U.A. Kloss, Gerhard F. Hamann   +5 more
openalex   +1 more source

Augmentation of Proliferation of Vascular Smooth Muscle Cells by Plasminogen Activator Inhibitor Type 1 [PDF]

, 2006
Yabing Chen, Ralph C. Budd, Robert J. Kelm, Burton E. Sobel, David J. Schneider   +4 more
openalex   +1 more source

A facultative plasminogen-independent thrombolytic enzyme from Sipunculus nudus

Nature Communications
Current thrombolytic therapies primarily function by converting plasminogen into plasmin, a process dependent on the fibrin–activator complex. This dependence, coupled with the substantial molecular size of plasmin, constrains its effectiveness in ...
Mingqing Tang, Guoxing Ma, Chunyan Xu, Hui Yang, Hongjun Lin, Chao Bian, Chengjia Hu, Meiling Lu, Lei Chen, Wencai Jie, Zhen Yue, Jianbo Jian, Yuqing Sun, Hui Yan, Jingjing Zhou, Xianying Zhang, Shengye Liao, Zhaofa Li, Shuangfeng Cai, Yaqing Wu, Kexin Yang, Yanan Xiong, Yonggang Zhao, Zhimin Lv, Xiaoming Xu, Chuang Liu, Pengliang Xin, Lichao Ye, Xiuling Cui, Qiong Shi, Xi Chen, Ruian Xu   +31 more
doaj   +1 more source

Clinical Policy: Use of Intravenous Tissue Plasminogen Activator for the Management of Acute Ischemic Stroke in the Emergency Department [PDF]

, 2015
Michael D. Brown, John H. Burton, Devorah J. Nazarian, Susan B. Promes, Stephen V. Cantrill, Michael D. Brown, Deena Brecher, Deborah B. Diercks, Seth R. Gemme, Charles J. Gerardo, Steven A. Godwin, Sigrid A. Hahn, Benjamin W. Hatten, Jason S. Haukoos, Amy Kaji, Bernard Lo, Sharon E. Mace, Devorah J. Nazarian, Mark C. Pierce, Susan B. Promes, Kaushal Shah, Richard D. Shih, Scott M. Silvers, Michael D. Smith, Christian Tomaszewski, Jonathan H. Valente, Stephen P. Wall, Stephen J. Wolf, Robert E. O’Connor, Rhonda R. Whitson   +29 more
openalex   +1 more source

Effect of dsRNA on Mesangial Cell Synthesis of Plasminogen Activator Inhibitor Type 1 and Tissue Plasminogen Activator [PDF]

, 2009
Markus Wörnle, Maximilian von Roeder, Matthias Sauter, Monika Merkle, Andrea Ribeiro   +4 more
openalex   +1 more source