Results 111 to 120 of about 3,479,441 (357)

A facultative plasminogen-independent thrombolytic enzyme from Sipunculus nudus

Nature Communications
Current thrombolytic therapies primarily function by converting plasminogen into plasmin, a process dependent on the fibrin–activator complex. This dependence, coupled with the substantial molecular size of plasmin, constrains its effectiveness in ...
Mingqing Tang, Guoxing Ma, Chunyan Xu, Hui Yang, Hongjun Lin, Chao Bian, Chengjia Hu, Meiling Lu, Lei Chen, Wencai Jie, Zhen Yue, Jianbo Jian, Yuqing Sun, Hui Yan, Jingjing Zhou, Xianying Zhang, Shengye Liao, Zhaofa Li, Shuangfeng Cai, Yaqing Wu, Kexin Yang, Yanan Xiong, Yonggang Zhao, Zhimin Lv, Xiaoming Xu, Chuang Liu, Pengliang Xin, Lichao Ye, Xiuling Cui, Qiong Shi, Xi Chen, Ruian Xu   +31 more
doaj   +1 more source

Long‐term remission in gout: Challenges and future opportunities

Rheumatology &Autoimmunity, EarlyView.
Prolonged hyperuricemia is a major risk factor for gout, which is now regarded as a curable disease. Awareness of the various factors that can trigger gout flares is essential for their prevention. An important determinant of treatment decisions and long‐term follow‐up is the quality of the clinician–patient relationship. The “treat‐to‐target” approach
Patapong Towiwat, Zhanguo Li
wiley   +1 more source

Clinical efficacy of low dose recombinant tissue-type plasminogen activator for the treatment of acute intermediate-risk pulmonary embolism [PDF]

, 2018
Lingyun Zhang, Baoan Gao, Zhu Jin, Guangming Xiang, Zheng Gong, Tingting Zhang, Hongfang Lu, Yongquan Wang, Yuan Gong, Lu Cheng, Weiling Huang   +10 more
openalex   +1 more source

eVLP‐Mediated Cas9 Delivery for Preventing IBMIR in Islet Transplantation

Small, EarlyView.
Engineered virus‐like particles (eVLPs) are used to deliver Cas9 nuclease to knock out tissue factor (TF) and plasminogen activator inhibitor‐1 (PAI‐1) genes in pancreatic islets. The edited islets maintained viability and function, while reducing instant blood‐mediated inflammatory reaction (IBMIR) markers and improving glycemic control in diabetic ...
Manju Shrestha, Yeonji Kim, Subin Park, Hu‐Lin Jiang, Jae‐Young Lee, Daesik Kim, Jee‐Heon Jeong   +6 more
wiley   +1 more source

Letter to the editor: Soluble urokinase plasminogen activator receptor and outcomes in HFpEF: A TOPCAT ancillary study

ESC Heart Failure, EarlyView.
Ahmed Raza, Shahzadi Gulfishan
wiley   +1 more source

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

Small Methods, EarlyView.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao   +9 more
wiley   +1 more source

Treatment of Hepatic Venocclusive Disease With Recombinant Human Tissue Plasminogen Activator and Heparin in 42 Marrow Transplant Patients [PDF]

, 1997
Scott I. Bearman, Jung Lim Lee, Anna E. Barón, George B. McDonald   +3 more
openalex   +1 more source

Chinese Guidelines for Diagnosis and Treatment of Chronic Rhinosinusitis (2024)

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Chronic rhinosinusitis (CRS), a complex inflammatory disease with heterogeneous pathogenesis, demands evolving evidence‐based strategies. Since the 2018 Chinese guidelines and EPOS2020, international advances in CRS immunopathology and biologics have revolutionized therapeutic approaches, particularly through phenotype–endotype classification ...
Subspecialty Group of Rhinology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery, Subspecialty Group of Rhinology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association   +4 more
wiley   +1 more source

Plasminogen activator inhibitor and the risk of cardiovascular disease: The Framingham Heart Study

, 2016
Geoffrey H. Tofler, Joseph M. Massaro, Chris O’Donnell, Peter W.F. Wilson, Ramachandran S. Vasan, Patrice Sutherland, James B. Meigs, Daniel Levy, Ralph B. D’Agostino   +8 more
openalex   +1 more source

Temporal changes in circulating P-selectin, plasminogen activator inhibitor-1, magnesium, and creatine kinase after percutaneous coronary intervention [PDF]

, 2010
Shu-qin Ying, Meixiang Xiang, Fang Lü, Jianan Wang   +3 more
openalex   +1 more source