Results 21 to 30 of about 3,530,803 (397)

Annexin A2-Mediated Plasminogen Activation in Endothelial Cells Contributes to the Proangiogenic Effect of Adenosine A2A Receptors

Frontiers in Pharmacology, 2021
Adenosine A2A receptor mediates the promotion of wound healing and revascularization of injured tissue, in healthy and animals with impaired wound healing, through a mechanism depending upon tissue plasminogen activator (tPA), a component of the ...
María D. Valls, María Soldado, Jorge Arasa, Jorge Arasa, Miguel Perez-Aso, Adrienne J. Williams, Bruce N. Cronstein, Bruce N. Cronstein, Bruce N. Cronstein, M. Antonia Noguera, M. Antonia Noguera, M. Carmen Terencio, M. Carmen Terencio, M. Carmen Montesinos, M. Carmen Montesinos   +14 more
doaj   +1 more source

Multifaceted Role of the Urokinase-Type Plasminogen Activator (uPA) and Its Receptor (uPAR): Diagnostic, Prognostic, and Therapeutic Applications

Frontiers in Oncology, 2018
The plasminogen activator (PA) system is an extracellular proteolytic enzyme system associated with various physiological and pathophysiological processes.
Niaz Mahmood, C. Mihalcioiu, S. Rabbani
semanticscholar   +1 more source

Yersinia pestis Plasminogen Activator

Biomolecules, 2020
The Gram-negative bacterium Yersinia pestis causes plague, a fatal flea-borne anthropozoonosis, which can progress to aerosol-transmitted pneumonia. Y.
Florent Sebbane, Vladimir N. Uversky, Andrey P. Anisimov   +2 more
doaj   +1 more source

In acute ischemic stroke patients with smoking incidence, are more women than men more likely to be included or excluded from thrombolysis therapy?

Women's Health, 2020
Background: Clinical factors associated with exclusion from recombinant tissue plasminogen activator in both men and women are not completely understood.
Oluyemi R Rotimi, Iretioluwa F Ajani, Alexandria Penwell, Shyyon Lari, Brittany Walker, Thomas I Nathaniel   +5 more
doaj   +1 more source

Inhibiting endogenous tissue plasminogen activator enhanced neuronal apoptosis and axonal injury after traumatic brain injury

Neural Regeneration Research, 2020
Tissue plasminogen activator is usually used for the treatment of acute ischemic stroke, but the role of endogenous tissue plasminogen activator in traumatic brain injury has been rarely reported.
Jun-Jie Zhao, Zun-Wei Liu, Bo Wang, Ting-Qin Huang, Dan Guo, Yong-Lin Zhao, Jin-Ning Song   +6 more
doaj   +1 more source

Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA [PDF]

, 2009
HGF (hepatocyte growth factor) is a pleiotropic cytokine homologous to the serine protease zymogen plasminogen that requires canonical proteolytic cleavage to gain functional activity.
Andrew M. Schumacher, Birchmeier, Bugge, Chirgadze, Collen, Deyi Qiu, Ellis, Ellis, Gherardi, Harris, Herter, Høyer-Hansen, Itoh, Jennifer L. Harris, Juliano Alves, Jun Li, Kate A. Owen, Ke, Kemp, Kilpatrick, Kirchhofer, Kirchhofer, Lamszus, Lee, Lynette M. Kilpatrick, Mangel, Marcotte, Mars, Mars, Matsuoka, Miyazawa, Mizuno, Mohammed, Naldini, Naldini, Qiu, Rahman, Riddick, Schmidt, Shanmukhappa, Shimizu, Shimomura, Steinmetzer, Stephens, Takeuchi, Uehara, Vincent Ellis, You   +47 more
core   +3 more sources

Reversal of cilioretinal artery occlusion with intra-arterial tissue plasminogen activator

American Journal of Ophthalmology Case Reports, 2017
Purpose: To present the reversal of a cilioretinal artery occlusion with the use of intra-arterial tissue plasminogen activator. Observations: A monocular 74 year old male presented with a cilioretinal artery occlusion.
Andrew J. McClellan, Harry W. Flynn, Jr., Eric C. Peterson, Norman J. Schatz   +3 more
doaj   +1 more source

Interaction of plasminogen and fibrin in plasminogen activation. [PDF]

Journal of Biological Chemistry, 1990
Glu1-, Lys77-, miniplasminogens, kringle 1-3, kringle 1-5A, and kringle 1-5R were able to bind with fibrin, while microplasminogen and kringle 4 did not bind significantly. Kringle 1-5A, but not kringle 1-3, effectively inhibited the binding of Glu1-, Lys77-, and miniplasminogens with fibrin.
Bi-Ing Chang, Guey Yueh Shi, Hua Lin Wu, K L Lou, Li-Ching Chang, C C Gong, Dung-Ho Wu   +6 more
openaire   +2 more sources

Spectrophotometric analysis of thrombolytic activity: SATA assay [PDF]

, 2017
Introduction: Measurement of thrombolytic activity i.e. clot lysis is crucial for research and development of novel thrombolytics. It is also a key factor in assessment of the effectiveness of conventionally used thrombolytic agents in the clinic, which ...
Entekhabi, Nazila, Eskandani, Morteza, Farhoudi, Mehdi, Mohammadian, Reza, Rafi, Mohammad, Zamanlu, Masumeh   +5 more
core   +2 more sources

Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury. [PDF]

, 2009
PurposeDeposition of fibrin in the alveolar space is a hallmark of acute lung injury (ALI). Plasminogen activator inhibitor-1 (PAI-1) is an antifibrinolytic agent that is activated during inflammation. Increased plasma and pulmonary edema fluid levels of
Brady, Sandra, Curley, Martha AQ, Flori, Heidi, Matthay, Michael A, Sapru, Anil   +4 more
core   +2 more sources